Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms
Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms
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DOI：
10.1136/thx.2006.060087
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发表时间：
2006-11-01
期刊：
影响因子：
10
通讯作者：
Morice, A. H.
中科院分区：
文献类型：
--
作者：
Ford, A. C.;Forman, D.;Morice, A. H.
背景：社区慢性咳嗽的患病率和严重程度尚不确定。在一个具有代表性的正常受试者的大群体中，我们探索了自我报告的咳嗽严重程度和频率之间的关系，以及已知与慢性咳嗽病因相关的因素。特别是，我们已经研究了咳嗽和胃肠道diseases.Methods症状之间的相对关联：进行了横断面调查，在36个一般的做法与实践计算机数据库中随机选择的主题。记录基线生活方式和人口统计学特征。参与者被问及在过去的2个月里他们经历咳嗽发作或痉挛的频率。使用咳嗽发作或痉挛的截止频率（每周一次至每天一次或以上）将咳嗽症状状态分为症状性。胃肠道数据收集使用验证methodology.Results：问卷发送到6416名受试者和4003（62%）回应。慢性咳嗽的患病率为12%，严重咳嗽的患病率为7%。多变量分析后，反流（OR 1.71; 99%CI 1.20 - 2.45）和肠易激综合征（OR 2.00; 99%CI 1.47 - 2.72）是咳嗽的强预测因子。吸烟（OR 1.61; 99%CI 1.18 ~ 2.19）、社会阶层下降（OR 1.63; 99%CI 1.04 ~ 2.57）和基线生活质量（OR 1.63; 99%CI 1.13 ~ 2.35）也显著相关。它与胃肠道疾病的密切联系可能具有病因学意义。
Background: The prevalence and severity of chronic cough in the community is uncertain. In a large population of representative normal subjects, we explored the relationship between self-reported cough severity and frequency, and factors known to be related to the aetiology of chronic cough. In particular, we have examined the relative association between cough and symptoms of gastrointestinal disease.Methods: A cross-sectional survey was undertaken in 36 general practices with subjects randomly selected from practice computer databases. Baseline lifestyle and demographic characteristics were recorded. Participants were asked how often in the previous 2 months they had experienced bouts or spasms of coughing. Cough symptom status was dichotomised into symptomatic using a cut off of bouts or spasms of coughing at a frequency of between once a week and once a day or above. Gastrointestinal data were collected using validated methodology.Results: Questionnaires were sent to 6416 subjects and 4003 ( 62%) responded. The prevalence of chronic cough was 12%, and was severe in 7%. Following multivariate analysis, regurgitation ( OR 1.71; 99% CI 1.20 to 2.45) and irritable bowel syndrome ( OR 2.00; 99% CI 1.47 to 2.72) were strong predictors of cough. Smoking ( OR 1.61; 99% CI 1.18 to 2.19), declining social class ( OR 1.63; 99% CI 1.04 to 2.57), and quality of life at baseline ( OR 1.63; 99% CI 1.13 to 2.35) were also significantly associated.Conclusion: Chronic cough is a common symptom in the general population. Its strong association with gastrointestinal disease may have aetiological significance.