Towards the Automatic Localization of the Irritative Zone Through Magnetic Source Imaging
Towards the Automatic Localization of the Irritative Zone Through Magnetic Source Imaging
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DOI：
10.1007/s10548-020-00789-y
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发表时间：
2020-08-07
期刊：
影响因子：
2.7
通讯作者：
Panzica, Ferruccio
中科院分区：
文献类型：
--
作者：
Luria, Gianvittorio;Duran, Dunja;Panzica, Ferruccio
本工作旨在验证贝叶斯多偶极子建模算法(SESAME)在临床场景中的有效性，该场景包括从静息状态脑磁图记录中定位单次发作间期癫痫样放电的发生器。我们使用专家用户进行的等效电流偶极子拟合的结果作为基准，并将SESAME的结果与两种广泛使用的声源定位方法RAP-MUSIC和WMNE的结果进行了比较。此外，我们还调查了手术结果与手术计划与所选脑叶的一致性之间的关系。与偶极子拟合不同，测试的算法不依赖于任何主观的通道选择，因此有助于使源定位更加无偏和自动化。结果表明，两种偶极子方法SESAME和RAP-MUSIC在识别脑叶方面与偶极子拟合法基本一致，前者的结果比后者更接近拟合电流偶极子的结果。此外，对于所有测试的方法，特别是对于芝麻，与手术计划的一致性是癫痫发作自由的良好预测因素，而不一致不是手术后不良结果的良好预测因素。结果表明，偶极子方法，特别是SESAME方法，在癫痫外科领域的临床应用中，是一种比人工偶极子拟合更可靠和更客观的方法。
The present work aims at validating a Bayesian multi-dipole modeling algorithm (SESAME) in the clinical scenario consisting of localizing the generators of single interictal epileptiform discharges from resting state magnetoencephalographic recordings. We use the results of Equivalent Current Dipole fitting, performed by an expert user, as a benchmark, and compare the results of SESAME with those of two widely used source localization methods, RAP-MUSIC and wMNE. In addition, we investigate the relation between post-surgical outcome and concordance of the surgical plan with the cerebral lobes singled out by the methods. Unlike dipole fitting, the tested algorithms do not rely on any subjective channel selection and thus contribute towards making source localization more unbiased and automatic. We show that the two dipolar methods, SESAME and RAP-MUSIC, generally agree with dipole fitting in terms of identified cerebral lobes and that the results of the former are closer to the fitted equivalent current dipoles than those of the latter. In addition, for all the tested methods and particularly for SESAME, concordance with surgical plan is a good predictor of seizure freedom while discordance is not a good predictor of poor post-surgical outcome. The results suggest that the dipolar methods, especially SESAME, represent a reliable and more objective alternative to manual dipole fitting for clinical applications in the field of epilepsy surgery.