Food demand functions in mice
Food demand functions in mice
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DOI：
10.1016/j.appet.2008.06.002
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发表时间：
2008-11-01
期刊：
影响因子：
5.4
通讯作者：
Rowland, Neil E.
中科院分区：
文献类型：
--
作者：
Chaney, Melissa A.;Rowland, Neil E.
使用混合 B6/129 背景的雄性小鼠（Mus musculus）来建立封闭经济中的食物需求函数。小鼠持续生活在操作室中，并以 20 毫克的全营养食物颗粒为食。首先，对每个颗粒实行一系列递增的固定比率（FR）成本，结果表明需求随着单价的增加而下降。每天的进餐次数取决于用于定义进餐的时间标准，但进餐次数在整个 FR 系列中没有变化。接下来，使用一系列渐进比例（PR）计划，并通过编程的计划重置间隔来定义膳食。在整个系列中，总食物摄入量略有下降，平均膳食量也有所下降。最后，将戳鼻子响应要求作为启动食品杠杆压紧装置的采购成本；在这种情况下，随着采购成本的增加，膳食数量发生了巨大变化，而总摄入量仅略有下降。这些数据表明，在小鼠身上，单价或消费成本的大幅变化对需求和膳食模式的影响相对较小，但少量的觅食（采购）成本却有很大的影响。 (C) 2008 Elsevier Ltd. 保留所有权利。
Male mice (Mus musculus) of a mixed B6/129 background were used to establish food demand functions in a closed economy. The mice lived continuously in operant chambers and worked for 20-mg nutritionally complete food pellets. First, a series of incrementing fixed ratio (FR) costs per pellet were imposed, and the results showed that demand declined as unit price increased. The number of meals taken per day was dependent on the temporal criterion used to define a meal, but the number of meals did not change across the FR series. Next, a series of incrementing progressive ratio (PR) schedules were used, and a meal was defined by a programmed schedule reset interval. Total food intake declined slightly, and the mean meal size also decreased, across the series. Lastly, a nose poke response requirement was imposed as the procurement cost to activate a lever press device for food; under these conditions the meal number changed dramatically as the procurement cost was increased, whereas total intake declined only modestly. These data show in mice that large changes in unit price or consummatory cost have relatively small effects on demand and meal patterns, but small amounts of foraging (procurement) cost have very large effects. (C) 2008 Elsevier Ltd. All rights reserved.