Impact of Insecticide Resistance on the Effectiveness of Pyrethroid-Based Malaria Vectors Control Tools in Benin: Decreased Toxicity and Repellent Effect.
Impact of Insecticide Resistance on the Effectiveness of Pyrethroid-Based Malaria Vectors Control Tools in Benin: Decreased Toxicity and Repellent Effect.
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DOI：
10.1371/journal.pone.0145207
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Akogbéto MC
中科院分区：
文献类型：
--
作者：
Agossa FR;Gnanguenon V;Anagonou R;Azondekon R;Aïzoun N;Sovi A;Oké-Agbo F;Sèzonlin M;Akogbéto MC
自1999年贝宁首次发现拟除虫菊酯耐药性证据以来，蚊子的突变迅速增加，现在很难设计一项包括疟疾病媒完全易感的控制区的研究。很少有研究评估抗性对蚊子种群中基于拟除虫菊酯的预防方法的成功的后效应。因此，我们评估了抗药性对拟除虫菊酯室内滞留喷洒（IRS）在半田间条件下和长效驱虫蚊帐（LLINs）在实验室条件下的有效性的影响。结果表明，拟除虫菊酯类化合物在供试种群中的驱避性和毒性均较低。室内滞留喷雾杀虫剂中使用的拟除虫菊酯的毒性显著低于安。gambiaes.l（< 46%），但其它优势种如非洲曼森氏菌（93%-97%）较高。与未处理的小屋相比，在表示为外亲性和威慑的驱避效果方面有显著差异（P<0.001）。此外，OlyseNet®的死亡率为23.71%，PermaNet®为39.06%。然而，对于实验室易感的“基苏穆”，两种蚊帐的死亡率均为100%，表明野生蚊子种群中存在抗性。因此，按照世界卫生组织建议的剂量使用拟除虫菊酯治疗在未来几年内将无法有效减少疟疾。因此，有必要研究杀虫剂抗药性如何降低拟除虫菊酯基病媒控制中使用的特定拟除虫菊酯的效力，以便采取有针对性的方法。
Since the first evidence of pyrethroids resistance in 1999 in Benin, mutations have rapidly increased in mosquitoes and it is now difficult to design a study including a control area where malaria vectors are fully susceptible. Few studies have assessed the after effect of resistance on the success of pyrethroid based prevention methods in mosquito populations. We therefore assessed the impact of resistance on the effectiveness of pyrethroids based indoor residual spraying (IRS) in semi-field conditions and long lasting insecticidal nets (LLINs) in laboratory conditions. The results observed showed low repulsion and low toxicity of pyrethroids compounds in the test populations. The toxicity of pyrethroids used in IRS was significantly low with An. gambiae s.l (< 46%) but high for other predominant species such as Mansonia africana (93% to 97%). There were significant differences in terms of the repellent effect expressed as exophily and deterrence compared to the untreated huts (P<0.001). Furthermore, mortality was 23.71% for OlyseNet® and 39.06% for PermaNet®. However, with laboratory susceptible “Kisumu”, mortality was 100% for both nets suggesting a resistance within the wild mosquito populations. Thus treatment with pyrethroids at World Health Organization recommended dose will not be effective at reducing malaria in the coming years. Therefore it is necessary to study how insecticide resistance decreases the efficacy of particular pyrethroids used in pyrethroid-based vector control so that a targeted approach can be adopted.