KAINIC-ACID-INDUCED SEIZURES - A DEVELOPMENTAL-STUDY
KAINIC-ACID-INDUCED SEIZURES - A DEVELOPMENTAL-STUDY
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DOI：
10.1016/0165-3806(84)90085-3
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
OKADA, R
中科院分区：
文献类型：
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作者：
ALBALA, BJ;MOSHE, SL;OKADA, R
在大鼠中生成红藻氨酸诱导癫痫发作的发育剂量-反应曲线。大鼠在15-18天（幼崽），33-37天（青春期）和超过90天（成年人）海人藻酸腹腔注射。癫痫发作引起的所有3个年龄组，但一些行为表现不同的幼崽。这组也有最低的惊厥阈值，最严重的癫痫发作和最高的死亡率。前肢抽搐和癫痫持续状态与成年和青春期的坏死性病变的发生有关，但在幼崽中则无关。脱氧葡萄糖（DG）放射自显影研究惊厥大鼠披露的DG摄取模式的黑质在3个年龄组的差异。DG摄取增加存在于2个年龄较大的组中，但不存在于幼仔中。由于最近的数据表明黑质是成年动物癫痫发作修饰电路的关键部位，因此幼仔中缺乏黑质参与可能是该年龄组癫痫发作早期泛化和严重程度增加的原因。
Developmental dose-response curves for kainic-acid-induced seizures were generated in rats. Rats at 15-18 days (pups), 33-37 days (pubescents) and over 90 days (adults) were administered kainic acid i.p. Seizures were elicited in all 3 age groups, but some of the behavioral manifestations differed in the pups. This group also had the lowest convulsive threshold, the most severe seizures and the highest mortality. Forelimb convulsions and status epilepticus were associated with the occurrence of necrotic lesions in the adults and pubescents but not in the pups. Deoxyglucose (DG) autoradiographic studies of the convulsing rats disclosed differences in the DG uptake pattern of the substantia nigra across the 3 age groups. Increased in the DG uptake were present in the 2 older age groups but not in the pups. Since recent data have implicated the substantia nigra as a crucial site in a seizure modifying circuitry in adult animals, the lack of substantia nigra involvement in the pups may account for the early generalization and the increased severity of seizures in this age group.