Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: Insights for understanding the impact of rotavirus vaccination programs
Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: Insights for understanding the impact of rotavirus vaccination programs
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DOI：
10.1016/j.vaccine.2011.09.111
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发表时间：
2012-04-27
期刊：
影响因子：
5.5
通讯作者：
Parashar, Umesh D.
中科院分区：
文献类型：
--
作者：
Banyai, Krisztian;Laszlo, Brigitta;Parashar, Umesh D.
最近，两种轮状病毒疫苗被推荐用于全世界婴儿的常规免疫接种。在发展中国家和发达国家的临床试验和实地使用过程中，这些疫苗被证明是有效的，并且似乎对一系列轮状病毒基因型提供了良好的保护，包括疫苗中未包括的一些轮状病毒。然而，由于仍然缺乏关于疫苗将保护免受多种轮状病毒毒株侵害的结论性数据，并且由于疫苗可能施加一些选择压力，因此，对于评估广泛引入轮状病毒疫苗后观察到的循环毒株的任何潜在变化，从前轮状病毒疫苗时代开始的全球毒株流行情况的详细情况非常重要。因此，我们系统地回顾了1996年至2007年12年间的轮状病毒基因分型研究。总共有来自100个报告国家的大约11万个菌株进行了基因分型。5个基因型（G1-G4和G9）占所有菌株的88%，尽管存在广泛的地理和时间差异。例如，G1株的流行率从2000年开始下降，而G3株重新出现，G9和G12株在同一时期出现。当根据区域对全球轮状病毒死亡率的贡献按区域对粗毒株流行率进行加权时，在死亡率低的区域更流行的G1和G9基因型毒株的重要性降低了，相反，在对全球轮状病毒死亡率贡献更大的非洲环境中更流行的G8毒株的重要性增加了。本研究提供了前轮状病毒疫苗时代最全面、最新的轮状病毒毒株监测信息，并将为研究轮状病毒疫苗引入对未来毒株流行的影响提供有用的背景。(C) 2011 Elsevier Ltd.版权所有。
Recently, two rotavirus vaccines have been recommended for routine immunization of infants worldwide. These vaccines proved efficacious during clinical trials and field use in both developing and developed countries, and appear to provide good protection against a range of rotavirus genotypes, including some that are not included in the vaccines. However, since conclusive data that the vaccines will protect against a wide variety of rotavirus strains are still lacking and since vaccines may exert some selection pressure, a detailed picture of global strain prevalence from the pre-rotavirus vaccine era is important to evaluate any potential changes in circulating strains observed after widespread introduction of rotavirus vaccines. Thus, we systematically reviewed rotavirus genotyping studies spanning a 12-year period from 1996 to 2007. In total, similar to 110,000 strains were genotyped from 100 reporting countries. Five genotypes (G1-G4, and G9) accounted for 88% of all strains, although extensive geographic and temporal differences were observed. For example, the prevalence of G1 strains declined from 2000 onward, while G3 strains re-emerged, and G9 and G12 strains emerged during the same period. When crude strain prevalence data were weighted by region based on the region's contribution to global rotavirus mortality, the importance of genotypes G1 and G9 strains that were more prevalent in regions with low mortality was reduced and conversely the importance of G8 strains that were more prevalent in African settings with greater contribution to global rotavirus mortality was increased. This study provides the most comprehensive, up-to-date information on rotavirus strain surveillance in the pre-rotavirus vaccine era and will provide useful background to examine the impact of rotavirus vaccine introduction on future strain prevalence. (C) 2011 Elsevier Ltd. All rights reserved.