ESSENTIAL MICRONUTRIENTS IN RELATION TO CARCINOGENESIS
ESSENTIAL MICRONUTRIENTS IN RELATION TO CARCINOGENESIS
复制标题
DOI：
10.1093/ajcn/45.5.1361
复制
发表时间：
1987-05-01
影响因子：
7.1
通讯作者：
KROMHOUT, D
中科院分区：
文献类型：
--
作者：
KROMHOUT, D
The essential micronutrients most commonly related to carcinogenesis are vitamins A, C, and E and selenium(1-3). Vitamin A intake and particularly$-carotene intake seem to be inversely related to lung cancer (4-16). Vitamin C intake is inversely related to stomach cancer (17-19). Etiologic studies on relations between vitamin E and selenium intake and mortality from different types of cancer have not been reported due to information on these micronutrients lacking in food tables. However, prospective case-control studies showed that cancer patients have significantly lower prediagnostic serum selenium levels than control subjects (20-22). The highest relative risk was observed for cancer patients who had both low serum selenium and low serum vitamin E levels compared with control subjects. These results suggest that the intake of the vitamin A, 9-carotene, vitamin C, vitamin E, and selenium may be of importance in relation to carcinogenesis. These micronutrients may be inversely related to carcinogenesis due to their antioxidant properties. Ames and coworkers hypothesized, mainly based on in vi-tro experiments, that uric acid is the most powerful antioxidant and scavenger of singlet oxygen and free radicals in the human body (23).
