BREAST LIVER METASTASES - INCIDENCE, DIAGNOSIS AND OUTCOME
BREAST LIVER METASTASES - INCIDENCE, DIAGNOSIS AND OUTCOME
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DOI：
10.1177/014107689108401207
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发表时间：
1991-12-01
影响因子：
17.3
通讯作者：
TAYLOR, I
中科院分区：
文献类型：
--
作者：
HOE, AL;ROYLE, GT;TAYLOR, I
乳腺肝转移是罕见的，并没有很好的报道。我们研究了1982年至1987年间接受治疗的912例乳腺癌患者中47例发生肝转移的临床结果，发生率为5.2%。临床肝转移前的中位无病间隔为20.2个月（范围4-192个月）。最常见的临床表现是肝肿大（70%）和腹痛（34%）。72.7%的患者经超声检查确诊。31名患者（70.5%）接受了激素和化疗的特异性治疗，但只有6名患者表现出客观反应，其中大多数患者仅在肝脏转移。接受治疗的患者的中位生存期为4个月，无黄疸、对治疗的反应和仅肝转移与显著提高的生存期相关。总之，乳腺肝转移通常是一种弥散性疾病的表现，预后很差。当它们发生在初始部位时，预后较好，但很少有患者对常规治疗有总体反应。
Breast liver metastases are uncommon and have not been well reported. We studied the clinical outcome of 47 patients who developed liver metastases out of 912 breast cancer patients treated between 1982 and 1987, an incidence of 5.2%.The median disease free interval prior to clinical liver metastases was 20.2 months (range 4-192 months). The most frequent clinical presentations were hepatomegaly (70%) and abdominal pain (34%). The diagnosis was confirmed on ultrasound scan in 72.7% patients.Thirty-one patients (70.5%) received specific treatment with both hormone and chemotherapy but only six showed any evidence of objective response, the majority of whom had metastases only in the liver.The median survival of treated patients was 4 months and absence of jaundice, response to treatment and liver metastases only were associated with significantly better survival.In conclusion breast liver metastases usually present as a manifestation of disseminated disease and have an appalling prognosis. When they occur as an initial site the prognosis is better but very few patients overall respond to conventional treatment.