COLORECTAL TUMORS AND PIT PATTERN
COLORECTAL TUMORS AND PIT PATTERN
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DOI：
10.1136/jcp.47.10.880
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发表时间：
1994-10-01
影响因子：
3.4
通讯作者：
YAGYUU, A
中科院分区：
文献类型：
--
作者：
KUDO, S;HIROTA, S;YAGYUU, A
目的-要调查的形态学和组织病理学之间的关联看到一个单独的坑立体显微镜或放大结肠镜和一个单独的隐窝中看到的组织切片，并检查这些协会在结直肠tumors. Methods-14023例结肠镜检查在秋田红十字会医院。在体内用放大内窥镜观察病变表面粘膜小凹，在体外用体视显微镜观察提取标本的小凹。结果：100个腺体的小凹类型分为7种主要类型：（1）正常圆形小凹;（2）小圆形小凹;（3）小星状小凹;（4）大星状小凹;（5）椭圆形小凹;（6）回状小凹;（7）无小凹。纹孔类型与下面的腺或腺的结构有一定的相关性。此外，有一个之间的联系，小坑模式和腺体中的细胞的组织学。大体上，3、4、5和6型常见于突出病变。2型多见于凹陷性病变。在这两种情况下，均识别出非凹坑模式。凹陷的病灶比突出的病灶更快地侵入深层。结论：个体的小凹和隐窝之间存在相关性。分支癌腺被认为是腺瘤腺恶性转化的结果。直腺癌被认为是正常腺体恶变的结果。小圆窝的腺体被认为是通过恶性转化从正常的直癌腺体变化。
Aims-To investigate the morphological and histopathological associations between an individual pit seen on stereomicroscopy or magnifying colonoscopy and an individual crypt seen in histological sections; and to examine these associations in colorectal tumours.Methods-Fourteen thousand and twenty three cases were examined by colonoscope at Akita Red Cross Hospital. The surface mucosal pits of the lesions were observed using a magnifying endoscope in vivo and the pits of the extracted specimens were observed in vitro using a stereo microscope. Histological diagnoses were determined by light microscopy: the pit patterns in 100 glands were analysed.Results-Pit pattern was classified into seven principal types: (1) normal round pit; (2) small round pit; (3) small asteroid pit; (4) large asteroid pit; (5) oval pit; (6) gyrus-like pit; and (7) non-pit. There was a correlation between pit pattern and the structure of the underlying crypt or gland. Furthermore, there was an association between pit pattern and the histology of the cells in the gland. Macroscopically, types 3, 4, 5, and 6 were common in protruding lesions. Type 2 was common in depressed lesions. The non-pit pattern was recognised in both. The depressed lesions had invaded the deeper layers more rapidly than protruding lesions.Conclusions-There were associations between individual pits and crypts. The branching carcinoma gland is thought to be the result of malignant transformation of the adenoma gland. The straight carcinoma gland is thought to result from the normal gland becoming malignant. The gland of the small round pit is thought to change from normal to the straight carcinoma gland via malignant transformation.