Iron homeostasis: new tales from the crypt.
Iron homeostasis: new tales from the crypt.
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DOI：
10.1182/blood.v96.13.4020.h8004020_4020_4027
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发表时间：
2000-12
期刊：
影响因子：
20.3
通讯作者：
Cindy N. Roy;C. Enns
中科院分区：
文献类型：
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作者：
Cindy N. Roy;C. Enns
肠上皮细胞是十二指肠上皮的高度特化的细胞，其协调铁的吸收和运输到体内。直到最近，铁吸收和铁稳态的分子机制仍然是一个谜。这篇综述着重于已知存在于肠上皮细胞前体细胞和成熟肠上皮细胞中的蛋白质和调控机制。最近克隆的基底外侧铁转运蛋白及其调控的调查提供了新的见解铁运输和稳态的可能机制。蛋白质，如铁调节蛋白，遗传性血色素沉着症蛋白（HFE）-转铁蛋白受体复合物，和hephaestin在调节这种转运蛋白和在调节铁转运整个肠上皮细胞的作用进行了讨论。一个投机的，但可测试的，铁稳态的维护模型，其中包括与肠上皮细胞的生命周期相关的铁相关蛋白的变化，因为它的旅程从隐窝的绒毛的尖端提出。
The enterocyte is a highly specialized cell of the duodenal epithelium that coordinates iron uptake and transport into the body. Until recently, the molecular mechanisms underlying iron absorption and iron homeostasis have remained a mystery. This review focuses on the proteins and regulatory mechanisms known to be present in the enterocyte precursor cell and in the mature enterocyte. The recent cloning of a basolateral iron transporter and investigations into its regulation provide new insights into possible mechanisms for iron transport and homeostasis. The roles of proteins such as iron regulatory proteins, the hereditary hemochromatosis protein (HFE)-transferrin receptor complex, and hephaestin in regulating this transporter and in regulating iron transport across the intestinal epithelium are discussed. A speculative, but testable, model for the maintenance of iron homeostasis, which incorporates the changes in the iron-related proteins associated with the life cycle of the enterocyte as it journeys from the crypt to the tip of the villous is proposed.