Prostate perfusion mapping using Fourier-transform based velocity-selective arterial spin labeling: Choice of cutoff velocity and comparison with brain.
Prostate perfusion mapping using Fourier-transform based velocity-selective arterial spin labeling: Choice of cutoff velocity and comparison with brain.
复制标题
使用基于傅里叶变换的速度选择性动脉自旋标记进行前列腺灌注图：截止速度的选择并与大脑进行比较。
DOI：
10.1002/mrm.29695
复制
发表时间：
2023
影响因子：
3.3
通讯作者：
Qin,Qin
中科院分区：
文献类型：
--
作者：
Liu,Dapeng;Zhu,Dan;Xu,Feng;Sedaghat,Farzad;Qin,Qin
目的开发用于前列腺血流（PBF）和前列腺血容量（PBV）绘图的速度选择性动脉自旋标记（VSASL）方案。方法在VSASL序列中利用基于傅立叶变换的速度选择性反转和饱和脉冲序列来分别获得血流和血容量加权灌注信号。这里，PBF 和 PBV 映射序列的四个截止速度（Vcut= 0.25、0.50、1.00 和 1.50cm/s）通过大脑中的并行实施进行评估，用于测量具有相同 3D 读数的脑血流量 (CBF) 和脑血容量 (CBV)。这项研究在 8 名中青年健康受试者上进行了 3T 比较，比较了灌注加权信号 (PWS) 和时间 SNR (tSNR)。结果与 CBF 和 CBV 相比，PBF 和 PBV 在 Vcut 为 1.00 或 1.50 cm/s 时相当难以观察到，并且 PBF 和 PBV 的 PWS 和 tSNR 在 Vcut 较低时显着增加，表明血液流动慢得多在前列腺中比在大脑中。与大脑结果类似，PBV 加权信号的 tSNR 大约是 PBF 加权信号相应值的两到四倍。结果还表明，衰老过程中前列腺内的血管供应有减少的趋势。结论对于前列腺，PBF 和 PBV 测量似乎需要 0.25-0.50cm/s 的低 Vcut，以获得足够的灌注信号。与大脑中一样，PBV 映射产生的 tSNR 高于 PBF。
PurposeTo develop velocity selective arterial spin labeling (VSASL) protocols for prostate blood flow (PBF) and prostate blood volume (PBV) mapping.MethodsFourier‐transform based velocity‐selective inversion and saturation pulse trains were utilized in VSASL sequences to obtain blood flow and blood volume weighted perfusion signal, respectively. Here four cutoff velocities (Vcut= 0.25, 0.50, 1.00, and 1.50 cm/s) for PBF and PBV mapping sequences were evaluated with a parallel implementation in brain for measuring cerebral blood flow (CBF) and cerebral blood volume (CBV) with identical 3D readout. This study was performed at 3T on eight young and middle‐aged healthy subjects comparing both perfusion weighted signal (PWS) and temporal SNR (tSNR).ResultsIn contrast to CBF and CBV, the PWS of PBF and PBV were rather unobservable at Vcutof 1.00 or 1.50 cm/s and both PWS and tSNR of PBF and PBV considerably increased at the lower Vcut, indicating that blood moves much slower in prostate than in brain. Similar to the brain results, the tSNR of PBV‐weighted signal was about two to four times over the corresponding values of PBF‐weighted signal. The results also suggested a trend of reduced vascularity within prostate during aging.ConclusionFor prostate, a low Vcutof 0.25–0.50 cm/s seemed necessary for both PBF and PBV measurements to obtain adequate perfusion signal. As in brain, PBV mapping yielded a higher tSNR than PBF.