A red-emissive benzothiazole-based luminophore with ESIPT and AIE natures and its application for detecting and imaging hypochlorous acid
A red-emissive benzothiazole-based luminophore with ESIPT and AIE natures and its application for detecting and imaging hypochlorous acid
复制标题
具有 ESIPT 和 AIE 性质的红色发射苯并噻唑基发光体及其在次氯酸检测和成像中的应用
DOI：
10.1016/j.saa.2022.121601
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Siping Tang
中科院分区：
文献类型：
--
作者：
Siyun Li;Ying Zeng;Can Tang;Feifei Wang;Biao Gu;Siping Tang
·合成了一种新型的基于“ESIPT + AIE”的苯并噻唑衍生物。·它在高水含量介质中显示出强的红色发射（606 nm），具有213 nm的斯托克斯位移。·可选择性检测HClO，响应速度快（12 s），灵敏度高。·可以观察活细胞中的内源性和外源性HClO。以2-（2′-羟基苯基）苯并噻唑为ESIPT结构单元，α -氰基二苯乙烯为AIE结构单元，合成了一种新型的“ESIPT + AIE”结构的苯并噻唑类红色荧光染料。BACN是一种理想的HClO化学传感器，其对HClO的荧光和比色响应是通过吸电子氰基激活的乙烯桥的HClO氧化断裂实现的。BACN在生理条件下能快速（12 s）灵敏地识别HClO，对其它生物相关物质具有良好的选择性。由于ESIPT和AIE效应的结合产生了强的红光发射（λ em = 606 nm）和大的Stokes位移（213 nm），它被成功地用于识别活HeLa细胞中的外源性和内源性HClO。
• A novel “ESIPT + AIE” based benzothiazole derivative was fabricated. • It showed strong red emission (606 nm) in high water content media with 213 nm Stokes shift. • It can selectively sense HClO with rapid response (12 s) and high sensitivity. • It can visualize the endogenous and exogenous HClO in living cells. A new “ESIPT + AIE” based dye of benzothiazole with red emission and a large Stokes shift was constructed by combining 2-(2′-hydroxyphenyl)benzothiazole as the ESIPT unit and α -cyanostilbene as the AIE unit. The compound BACN was found to be a ideal HClO chemosensor, and presented palpable fluorescence and colorimetric responses toward HClO via the HClO-trigged oxidation cleavage of the ethylene bridge activated by the electron withdrawing cyano group. BACN was capable of recognizing HClO rapidly (12 s) and sensitively under physiological conditions, with good selectivity over other biologically pertinent substances. Thanks to strong red emission ( λ em = 606 nm) and large Stokes shift (213 nm) resulted from the combination of ESIPT and AIE effects, it was successfully utilized for the recognition of exogenous and endogenous HClO in living HeLa cells.