Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
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DOI：
10.1093/ajcn/80.4.992
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发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
--
作者：
den Heijer, T;Vermeer, SE;Breteler, MMB
背景：与戒酒者相比，轻度至中度饮酒者患痴呆症和阿尔茨海默病的风险较低。由于血管疾病可能导致阿尔茨海默病的症状，因此少量饮酒的消费者脑血管疾病的减少可以解释这一观察结果。然而，低浓度的酒精也可能对海马体产生直接影响，海马体是阿尔茨海默病高度影响的脑结构。目的：探讨酒精摄入与脑磁共振成像（MRI）结果的关系（即，白色物质病变和梗死）和在早期阿尔茨海默病中更特异性发现的发现设计：在1074名无痴呆的老年人（年龄60-90岁）的人群样本中，我们进行了脑MRI，从中我们对白色病变和脑梗死进行了评级。在一个509人的子集中，测量了MRI上的海马和杏仁核体积。酒精摄入量通过使用结构化问卷进行评估。我们将酒精摄入量分为终身饮酒和非常少量（
Background: Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease may contribute to symptoms of Alzheimer disease, reduction of cerebrovascular disease in consumers of light amounts of alcohol could account for that observation. However, a low concentration of alcohol may also have direct effects on the hippocampus, a brain structure highly affected by Alzheimer disease.Objective: We investigated alcohol intake in relation to brain magnetic resonance imaging (MRI) findings of presumed vascular origin (ie, white matter lesions and infarcts) and findings more specifically found in early Alzheimer disease (ie, hippocampal and amygdalar atrophy).Design: In a population-based sample of 1074 older persons without dementia (aged 60-90 y), we made brain MRIs from which we rated white matter lesions and brain infarcts. In a subset of 509 people, hippocampal and amygdalar volumes on MRI were measured. Alcohol intake was assessed by using a structured questionnaire. We categorized alcohol intake as lifetime abstention and very light (