POLY[(AMINO-ACID-ESTER)PHOSPHAZENES] - SYNTHESIS, CRYSTALLINITY, AND HYDROLYTIC SENSITIVITY IN SOLUTION AND THE SOLID-STATE
POLY[(AMINO-ACID-ESTER)PHOSPHAZENES] - SYNTHESIS, CRYSTALLINITY, AND HYDROLYTIC SENSITIVITY IN SOLUTION AND THE SOLID-STATE
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DOI：
10.1021/ma00083a001
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发表时间：
1994-02-28
期刊：
影响因子：
5.5
通讯作者：
SCOPELIANOS, AG
中科院分区：
文献类型：
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作者：
ALLCOCK, HR;PUCHER, SR;SCOPELIANOS, AG
合成了15种不同的聚[氨基酸酯]磷腈，研究了它们在溶液和固体中的结晶性质和水解行为。合成的聚磷腈有聚[二(甲基甘氨酸N-基)磷腈]、聚[二(乙基甘氨酸N-基)磷腈]、聚[二(叔丁基甘氨酸N-基)磷腈]、聚[二(丙二酸苄基-N-基)磷腈]、聚[二(甲基丙氨酸基-N-基)磷腈]、聚[二(乙基丙氨酸基-N-基)磷腈]、聚[二(叔丁基丙氨基-N-基)磷腈]、聚[二(叔丁基丙氨基-N-基)磷腈]、聚[二(丁基丙二酸基-N-基)磷腈]、聚[二(叔丁基丙二酸基)膦]、聚[二(丁基丙二酸基-N-基)磷腈]、聚[二(丁基丙二酸基-N-基)磷腈]、聚[二(叔丁基丙氨基-N-基)磷腈]、聚[二(丁基丙二酸基-N-基)磷腈]、聚[二(叔丁基丙二酸基-N-基)磷腈]、聚[二(叔丁基丙氨基-N-基)磷腈]、聚[二(叔丁基丙氨基-N-基)膦]、聚[二(叔丁基丙氨基-N-基)膦]、聚[二(叔丁基丙氨基-N-基)膦聚[双(甲基呋喃-N-基)磷腈]、聚[双(乙基-N-基)磷腈]、聚[双(叔丁基-N-基)磷腈]、聚[双(苯丙氨基-N-基)磷腈]、聚[双(甲基苯丙氨酸-N-基)磷腈]、聚[双(乙基苯丙氨基-N-基)磷腈]和聚[双(叔丁基苯丙氨基-N-基)磷腈]。通过大量过量适当的氨基酸酯处理聚二氯磷腈，得到了全取代聚合物。用差示扫描量热法和偏光显微镜测定，其中几种聚合物是结晶的。进行了水解研究，以估计聚合物的分解速度和聚合物保持其结构完整性的持续时间。这些聚合物是潜在的生物医学材料。
Fifteen different poly[(amino acid ester)phosphazenes] were synthesized to study their crystalline character and hydrolysis behavior in the solution and solid states. The polyphosphazenes synthesized were poly[bis(methyl glycinat-N-yl)phosphazene], poly[bis(ethyl glycinat-N-yl)phosphazene], poly[bis(tert-butyl glycinat-N-yl)phosphazene], poly[bis(benzyl glycinat-N-yl)phosphazene], poly[bis(methyl alaninat-N-yl)phosphazene], poly[bis(ethyl alaninat-N-yl)phosphazene], poly[bis(tert-butyl alaninat-N-yl)phos-phazene], poly[bis(benzyl alaninat-N-yl)phosphazene], poly[bis(methyl valinat-N-yl)phosphazene], poly-[bis(ethyl valinat-N-yl)phosphazene], poly[bis(tert-butyl valinat-N-yl)phosphazene],poly[bis(benzyl valinat-N-yl)phosphazene], poly[bis(methyl phenylalaninat-N-yl)phosphazene], poly[bis(ethyl phenylalaninat-N-yl)phosphazene], and poly[bis(tert-butyl phenylalaninat-N-yl)phosphazene]. The fully-substituted polymers were obtained by treatment of poly(dichlorophosphazene) with a large excess of the appropriate amino acid ester. Several of these polymers were crystalline as measured by differential scanning calorimetry and by polarized optical microscopy. Hydrolysis studies were performed to estimate the rates of decomposition of the polymers and the duration over which the polymers maintained their structural integrity. The polymers are potential biomedical materials.