Hepatoma-derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation
Hepatoma-derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation
复制标题
肝癌源性生长因子通过 Erk1/2 激活促进细胞增殖参与胃上皮细胞癌变
DOI：
10.1111/j.1349-7006.2008.00928.x
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发表时间：
2008-11-01
期刊：
影响因子：
5.7
通讯作者：
Zhu, Yongliang
中科院分区：
文献类型：
--
作者：
Mao, Jianshan;Xu, Zefeng;Zhu, Yongliang
肝癌衍生生长因子（Hepatoma-derived growth factor，HDGF）与肿瘤的发生、发展有关，是影响肝癌、非小细胞肺癌和胰腺癌预后的独立因素。然而，HDGF参与胃癌发生发展的分子机制及其在胃癌前病变发生发展过程中的功能调控还有待进一步研究。本研究观察了HDGF转染对胃癌AGS细胞增殖的影响，以及对丝裂原活化蛋白激酶（MAPK）、Akt和核因子-κ B（NF-kappa B）通路的影响。HDGF转染显著激活AGS细胞中的Erk 1/2，并促进非贴壁依赖性生长。进一步的研究表明，HDGF在胃癌发生过程中表达逐渐增加，且在易发生淋巴转移的低分化腺癌中呈高表达，提示HDGF参与了胃癌的发生过程，并通过激活Erk 1/2促进增殖和转移。（Cancer Sci 2008; 99：2120-2127）。
Hepatoma-derived growth factor (HDGF) is related to tumorigenesis and the development of cancer; it is an independent factor associated with the prognosis of liver cancer, non-small cell lung cancer and pancreatic cancer. However, the molecular mechanism by which HDGF participates in gastric carcinogenesis and development as well as its functional regulation during the development of gastric precancerous lesions needs to be further analyzed. In the present study, we analyzed the effect of HDGF transfection on the proliferation and on the changes of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kappa B (NF-kappa B) pathways in gastric cancer AGS cells. HDGF transfection significantly activated Erk1/2 in AGS cells and promoted anchorage-independent growth. Further studies showed that HDGF expression gradually increased in the gastric carcinogenesis process and HDGF showed a high expression in poorly differentiated adenocarcinoma prone to lymphoid metastasis; these findings suggest that HDGF is involved in the gastric carcinogenesis process and promotes proliferation and metastasis via Erk1/2 activation. (Cancer Sci 2008; 99: 2120-2127).