Sexual risk for hepatitis B virus infection among hepatitis C virus-negative heroin and cocaine users
Sexual risk for hepatitis B virus infection among hepatitis C virus-negative heroin and cocaine users
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DOI：
10.1017/s0950268805005248
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发表时间：
2006-06-01
影响因子：
4.2
通讯作者：
Stein, M. D.
中科院分区：
文献类型：
--
作者：
Rich, J. D.;Anderson, B. J.;Stein, M. D.
丙型肝炎病毒（HCV）和B肝炎病毒（HBV）在吸毒者中高度流行，经常同时发生感染。我们研究了一组HCV阴性的海洛因和/或可卡因使用者中HBV的流行率和风险行为模式，以了解这一独特群体中HBV的风险和预防机会。在164名参与者中，44%的人注射过毒品。总体而言，24%的参与者暴露于HBV检测呈阳性;药物注射者（28%）比从未注射过药物的人（21%）检测呈阳性的可能性仅为轻微且不显著（P = 0.287）。HBV暴露与性别风险更大的多个指标显著相关。HBV状态与任何人口统计学特征无关，但报告可卡因使用持续时间较长的参与者对HBV暴露的检测呈阳性的可能性显着降低。在这一队列中，HCV阴性吸毒者的HBV风险似乎主要是由于性行为。
Hepatitis C virus (HCV) and hepatitis B virus (HBV) are highly prevalent, often co-occuring infections among drug users. We examined HBV prevalence and risk behaviour patterns among a group of HCV-negative heroin and/or cocaine users in order to understand HBV risk and prevention opportunities among this unique group. Of 164 people enrolled, 44% had injected drugs. Overall, 24% of participants tested positive for exposure to HBV; drug injectors (28%) were only slightly and not significantly (P = 0.287) more likely to test positive than those who had never injected drugs (21%). HBV exposure was significantly associated with multiple indicators of greater sex risk. HBV status was not associated with any demographic characteristic, but participants who reported longer duration of cocaine use were significantly less likely to test positive to exposure for HBV. It appears that HBV risk among HCV-negative drug users in this cohort is primarily due to sexual behaviour.