Estrogen Receptor-α Polymorphisms and Predisposition to TMJ Disorder
Estrogen Receptor-α Polymorphisms and Predisposition to TMJ Disorder
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DOI：
10.1016/j.jpain.2008.11.012
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发表时间：
2009-05-01
期刊：
影响因子：
4
通讯作者：
Rizzatti Barbosa, Celia Marisa
中科院分区：
文献类型：
--
作者：
Ribeiro-Dasilva, Margarete Cristiane;Peres Line, Sergio Roberto;Rizzatti Barbosa, Celia Marisa
颞下颌关节紊乱病（TMJD）影响女性的频率高于男性，性激素可能有助于这种女性优势。因此，本研究调查了雌激素受体α（Xbal/Pvull）单核苷酸多态性（SNP）是否与女性TMJD相关。根据颞下颌关节紊乱病研究诊断标准（RDC/TMD），从200名患有TMJD的妇女（100名患有慢性疼痛，100名有TMJD症状但没有疼痛）和100名没有TMJD的对照妇女中获得DNA。采用聚合酶链反应产物的限制性片段长度多态性分析DNA片段中Xbal和Pvull的SNPs。使用基于EM算法实现的风险单倍型结构直接表征特定DNA序列变体的模型来分析数据。与对照组相比，两个TMJD组中Xbal基因座的[GC]单倍型显著更普遍（P = .0012）。具体而言，[GC]单倍型在疼痛TMJD组中比对照组更普遍（OR 3.203，95%CI = 1.633，6.284），在TMJD无疼痛组中比对照组更普遍（OR = 2.51，95%CI 1.267，4.97）。总之，[GC]单倍型在Xbal基因座的存在可能会增加妇女的易感性发展TMJD.Perspective：这项研究表明，在雌激素受体的多态性可能会增加妇女发展颞下颌关节紊乱的风险。这一发现可能阐明雌激素对TMJD的贡献的个体间差异，对TMJD易感性的遗传影响，并可能作为未来治疗定制的基础，这可能会提高这些患者的预后。(C)2009年美国疼痛协会
Temporomandibular joint disorders (TMJD) affect women with greater frequency than men, and sex hormones may contribute to this female predominance. Therefore, this study investigated whether estrogen receptor-alpha (Xbal/Pvull) single nucleotide polymorphisms (SNPs) are associated with TMJD in women. DNA was obtained from 200 women with TMJD (100 with chronic pain and 100 with signs of TMJD but no pain) diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorder (RDC/TMD) and 100 control women without TMJD. Restriction fragment length polymorphisms of polymerase chain reaction products were used to analyze Xbal and Pvull SNPs in DNA fragments. A model directly characterizing specific DNA sequence variants based on the risk haplotypic structure implemented with the EM algorithm was used to analyze the data. The [GC] haplotype of the Xbal locus was significantly more prevalent in both TMJD groups when compared with the control group (P = .0012). Specifically, the [GC] haplotype was more prevalent within the painful TMJD group versus the control group (OR 3.203, 95% CI = 1.633, 6.284) and in the TMJD no pain versus the control group (OR = 2.51, 95% CI 1.267, 4.97). In conclusion, the presence of [GC] haplotype in the Xbal locus may increase the susceptibility of women to develop TMJD.Perspective: This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. This finding may elucidate the interindividual differences in the contribution of estrogen to TMJD, the genetic influences on TMJD predisposition, and may serve as the basis for future treatment tailoring, which could enhance outcomes for these patients. (C) 2009 by the American Pain Society