Role of hippocampal activity-induced transcription in memory consolidation.
Role of hippocampal activity-induced transcription in memory consolidation.
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DOI：
10.1515/revneuro-2016-0010
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发表时间：
2016-08-01
影响因子：
4.1
通讯作者：
Robison AJ
中科院分区：
文献类型：
--
作者：
Eagle AL;Gajewski PA;Robison AJ
海马（HPC）神经元之间连接强度的经验依赖性变化对于正常学习和记忆巩固至关重要，而这一过程的中断会导致各种神经和精神疾病。适当的HPC功能依赖于由神经元活动诱导的转录因子（TF）驱动的基因表达的离散变化。在这里，我们描述了许多研究最充分的HPC TF的诱导和功能，包括环AMP反应元件结合蛋白，血清反应因子，AP-1等，并描述了它们在学习过程中的作用。我们还讨论了已知的靶基因的许多这些TF和所谓的机制，他们调节HPC突触强度的长期变化。此外，我们建议，在这一领域的未来研究将取决于这些活动依赖性TF和随后的荟萃分析，确定共同的基因或途径，在学习或疾病的HPC中的多个TF调节的额外的基因靶点的公正鉴定。
Experience-dependent changes in the strength of connections between neurons in the hippocampus (HPC) are critical for normal learning and memory consolidation, and disruption of this process drives a variety of neurological and psychiatric diseases. Proper HPC function relies upon discrete changes in gene expression driven by transcription factors (TFs) induced by neuronal activity. Here, we describe the induction and function of many of the most well-studied HPC TFs, including cyclic-AMP response element binding protein, serum-response factor, AP-1, and others, and describe their role in the learning process. We also discuss the known target genes of many of these TFs and the purported mechanisms by which they regulate long-term changes in HPC synaptic strength. Moreover, we propose that future research in this field will depend upon unbiased identification of additional gene targets for these activity-dependent TFs and subsequent meta-analyses that identify common genes or pathways regulated by multiple TFs in the HPC during learning or disease.