Beneficial effects of fasting regimens on periodontal tissues in experimental periodontitis mice model
Beneficial effects of fasting regimens on periodontal tissues in experimental periodontitis mice model
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发表时间：
2018
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通讯作者：
L. K. Wulansari;B. Kaboosaya;Masud Khan;Mariko Takahashi;Hidemi Nakata;S. Kuroda;KazuhiroAoki;
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作者：
L. K. Wulansari;B. Kaboosaya;Masud Khan;Mariko Takahashi;Hidemi Nakata;S. Kuroda;KazuhiroAoki;
以前的研究表明，禁食对整体健康有益，延长寿命，并使细胞恢复活力，促进组织再生。牙周炎是一种常见的口腔炎症性疾病，可导致牙槽骨丢失，并与几种系统性健康问题有关。结扎诱导的牙周炎模型被认为在许多方面与人类牙周炎相似，是牙周病研究中最常用的动物模型之一。本研究旨在探讨禁食对实验性牙周炎的影响。在这项研究中，我们采用了两种不同的禁食方案：间歇性禁食（IF /每隔一天禁食）和延长禁食（PF / 2天禁食和5天自由进食）4周。我们发现，两个禁食方案组相比，非禁食组在结扎牙周炎部位的骨丢失量较少，而且在上颌骨的对侧也发生了生理性骨丢失。PQCT和钙黄绿素标记的组织形态计量学分析显示，禁食组的骨再生能力高于非禁食组。禁食组股骨的骨髓细胞比非禁食组产生更多的矿化模块。这项研究的数据显示，禁食有利于抵抗牙周炎中的骨破坏和维持牙周骨健康，这可能是由于骨髓中骨祖细胞的增加。研究文章（J Int Dent Med Res 2018; 11（2）：pp.（第362-369段）
Previous studies demonstrated that fasting has beneficial effects on overall health, extending lifespan and that it rejuvenates cells, promoting tissue regeneration. Periodontitis is a prevalent oral inflammatory disease that leads to alveolar bone loss and linked to several systemic health problems. Ligature-induced periodontitis model is considered to be similar to human periodontitis in various aspect and is one of the most used animal models in periodontal research. The present study aims to investigate the effect of fasting regimen in experimentally-induced periodontitis in mice. In this study we applied two different kinds of fasting regimens: Intermittent fasting (IF / every other day fasting)and prolonged fasting (PF / 2 days fasting and 5 days free food intake) for 4 weeks. We found that both fasting regimen groups showed less amount of bone loss compared to the nonfasting groups at the ligature-periodontitis site, furthermore also at the contralateral side of the maxillae where the physiological bone loss occurs. PQCT and calcein-labeled histomorphometric analyses showed higher bone regeneration capacity in the fasting groups than in the nonfasting groups. Bone marrow cells from the femurs of the fasting groups produced more mineralized modules than the nonfasting groups. Data from this study showed fasting would be beneficial for resisting bone destruction in periodontitis and for maintaining periodontal bone health, which could be due to the increase of osteoprogenitor cells in bone marrow. Research article (J Int Dent Med Res 2018; 11(2): pp. 362-369)