Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase
Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase
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DOI：
10.1016/j.chemosphere.2020.128029
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发表时间：
2021-01-01
期刊：
影响因子：
8.8
通讯作者：
Bezerra, Ranilson S.
中科院分区：
文献类型：
--
作者：
Azevedo, Rafael D. S.;Falcao, Kivia V. G.;Bezerra, Ranilson S.
吡丙醚是世界范围内使用的一种杀虫剂，作为一种仿生学的幼年激素。本研究以斑马鱼乙酰胆碱酯酶（zbAChE）和线粒体为标记物，研究了吡丙醚引起的代谢和突触损伤。在吡丙醚浓度范围（0.001-10 μ mol/L）范围内进行脑zbAChE体外和体内测定，以评估抑制动力学。
Pyriproxyfen is an insecticide used worldwide that acts as a biomimetic of juvenile hormone. This study investigated metabolic and synaptic impairments triggered by pyriproxyfen using zebrafish acetylcholinesterase (zbAChE) and mitochondria as markers. A brain zbAChE assay was performed in vitro and in vivo covering a range of pyriproxyfen concentrations (0.001-10 mu mol/L) to assess inhibition kinetics.