Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand
Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand
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DOI：
10.1016/j.jhin.2019.04.004
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发表时间：
2019-10-01
影响因子：
6.9
通讯作者：
Cooper, B. S.
中科院分区：
文献类型：
--
作者：
Roberts, T.;Limmathurotsakul, D.;Cooper, B. S.
在南亚和东南亚，耐抗生素的革兰氏阴性菌是住院新生儿发病和死亡的主要原因。本研究旨在确定泰国新生儿重症监护病房（NICU）患者中耐抗生素革兰氏阴性菌定植的动态。在97例入组患者中，52%在住院期间的某个时间点被超广谱β-内酰胺酶（ESBL）微生物定植，64%被碳青霉烯类耐药微生物定植。发现ESBL阳性和碳青霉烯类耐药微生物的快速获得。一旦被耐药微生物定植，患者在NICU停留的剩余时间内仍保持定植。(C)2019作者（S）由Elsevier Ltd代表The Healthcare Infection Society出版。
Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum beta-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay. (C) 2019 The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society.