Nicotine and carbon monoxide exposure from inhalation of cigarillo smoke.
Nicotine and carbon monoxide exposure from inhalation of cigarillo smoke.
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DOI：
10.1016/j.pbb.2015.10.007
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Pickworth WB
中科院分区：
文献类型：
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作者：
Koszowski B;Rosenberry ZR;Kanu A;Viray LC;Potts JL;Pickworth WB
在美国，小雪茄的使用量有所增加。抽小雪茄的人通常也经常抽香烟（双重使用者）。在两个实验阶段，我们比较了双重使用者（N=23）的雾化地形、急性暴露的生物标志物[呼出一氧化碳（COex）和血浆尼古丁]和普通品牌香烟和黑淡雪茄的生理影响。参与者（21名男性）平均每天抽17.5支烟。小雪茄的摄入量变化很大，少则一周一次，多则每天一次。参与者高度依赖尼古丁（平均FTND得分：6.3）。吸烟行为在吸烟时间、吞吐次数、总吞吐量等方面均有统计学差异（P<0.001）。香烟和小雪茄的平均吞吐时间、吞吐间隔、吞吐量和吞吐速度没有差异。吸完香烟和小雪茄后，尼古丁的增加是相似的。与吸烟相比，小雪茄对COex的促进作用明显更大（P<0.001）。吸烟模式和暴露情况表明，双重使用者吸入小雪茄烟雾就像吸入香烟烟雾一样，从而使自己暴露于相当数量的尼古丁和烟草烟雾的其他成分。COex暴露结果表明，与卷烟相比，吸食小雪茄可能与主流小雪茄烟雾中挥发性成分（包括致癌物）的暴露程度较高有关。小雪茄和香烟在双重使用者中吸食相似的研究结果与雪茄产品的健康和监管考虑有关。
There has been an increase in the use of cigarillos in the US. People who smoke cigarillos typically also regularly smoke cigarettes (dual users). We compared puffing topography, biomarkers of acute exposure [exhaled carbon monoxide (COex) and plasma nicotine] and physiologic effects from usual brand cigarette and Black & Mild cigarillo smoking in dual users (N=23) in two laboratory sessions. Participants (21 men) smoked an average of 17.5 cigarettes/day. Cigarillo consumption varied widely from as few as 1/week to daily. Participants were highly nicotine dependent (average FTND score: 6.3). There were statistically significant differences in smoking behavior between cigarette and cigarillo smoking in time to smoke, number of puffs, and total puff volume (all P<0.001). Average puff duration, interpuff interval average puff volume, and puff velocity did not differ between cigarettes and cigarillos. Nicotine boost was similar after both cigarettes and cigarillos. COex boost was significantly greater after cigarillo smoking compared to cigarette smoking (P<0.001). The smoking pattern and exposure profile indicate that dual users inhale cigarillo smoke just as they inhale cigarette smoke thereby exposing themselves to considerable amounts of nicotine and other components of tobacco smoke. COex exposure results imply that cigarillo smoking may be associated with higher exposure to smoke-delivered volatile components of mainstream cigarillo smoke including carcinogens when compared to cigarettes. The findings that cigarillos and cigarettes are smoked similarly in dual users are relevant to health and regulatory considerations on cigar products.