Association of a Polymorphism of BTN2A1 With Hypertension in Japanese Individuals
Association of a Polymorphism of BTN2A1 With Hypertension in Japanese Individuals
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DOI：
10.1038/ajh.2011.74
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发表时间：
2011-08-01
影响因子：
3.2
通讯作者：
Yamada, Yoshiji
中科院分区：
文献类型：
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作者：
Horibe, Hideki;Kato, Kimihiko;Yamada, Yoshiji
背景我们之前表明，嗜丁酸蛋白亚家族2成员A1基因（BTN2A1）的C.T多态性（rs6929846）与日本人的心肌梗死相关。鉴于高血压是心肌梗死的主要危险因素，BTN2A1 rs6929846 与心肌梗死的关联可能至少部分归因于其对高血压易感性的影响。因此，我们检查了 BTN2A1 rs6929846 与日本个体高血压的关系。 方法 对来自两个独立受试者组的总共 8,567 名日本个体进行了检查：受试者组 A 和 B 分别包括 2,317 名高血压个体和 1,933 名对照者，以及 2,911 名高血压个体和 1,406 名对照者。通过将 PCR 和序列特异性寡核苷酸探针与悬浮阵列技术相结合的方法确定 rs6929846 的基因型。 结果调整协变量的多变量逻辑回归分析显示，BTN2A1 的 rs6929846 与受试者组 A 中的高血压显着相关（P = 2.6 x 10-6；比值比， 1.69）和受试者组 B（P = 0.0284；优势比，1.24）中，T 等位基因代表高血压的危险因素。 rs6929846 与受试者组 A ( P = 0.0063) 和 B ( P = 0.0115) 中的收缩压 ( BP) 相关，以及受试者组 B 中的舒张压 ( P = 0.0323) 相关，其中 T 等位基因与高血压相关。 结论 SBTN2A1 可能是日本人高血压的易感基因。确定这种多态性的基因型可能为评估高血压的遗传风险提供信息。
BACKGROUNDWe previously showed that the C. T polymorphism (rs6929846) in butyrophilin, subfamily 2, member A1 gene (BTN2A1) was associated with myocardial infarction in Japanese individuals. Given that hypertension is a major risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to hypertension. We have thus examined the relation of rs6929846 of BTN2A1 to hypertension in Japanese individuals.METHODSA total of 8,567 Japanese individuals from two independent subject panels were examined: Subject panels A and B comprised 2,317 hypertensive individuals and 1,933 controls, and 2,911 hypertensive individuals and 1,406 controls, respectively. The genotype of rs6929846 was determined by a method that combines the PCR and sequence- specific oligonucleotide probes with suspension array technology.RESULTSMultivariable logistic regression analysis with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with hypertension in subject panel A ( P = 2.6 x 10- 6; odds ratio, 1.69) and in subject panel B ( P = 0.0284; odds ratio, 1.24), with the T allele representing a risk factor for hypertension. The rs6929846 was associated with systolic blood pressure ( BP) in subject panels A ( P = 0.0063) and B ( P = 0.0115) and with diastolic BP in subject panel B ( P = 0.0323), with the T allele being related to high BP.CONCLUSIONSBTN2A1 may be a susceptibility gene for hypertension in Japanese individuals. Determination of genotype for this polymorphism may prove informative for assessment of the genetic risk for hypertension.