Changes in cross-frequency coupling following closed-loop auditory stimulation in non-rapid eye movement sleep
Changes in cross-frequency coupling following closed-loop auditory stimulation in non-rapid eye movement sleep
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DOI：
10.1038/s41598-020-67392-w
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发表时间：
2020-06-30
影响因子：
4.6
通讯作者：
Huber, Reto
中科院分区：
文献类型：
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作者：
Krugliakova, Elena;Volk, Carina;Huber, Reto
非快速眼动(NREM)睡眠增量和Sigma活动的区域性变化以及它们的时间耦合与先前清醒时经验依赖性的可塑性变化有关。这些睡眠特有的节律似乎对大脑恢复和巩固记忆很重要。最近，有研究表明，通过闭合听觉刺激在特定时相定位特定区域的慢波，有可能局部操纵慢波活动，并与训练诱导的神经可塑性变化相互作用。在我们的研究中，我们测试了以慢波上相为目标的闭环听觉刺激是否不仅与主要睡眠节律相互作用，而且与其在限定区域内的耦合作用。我们证明，虽然闭环式听觉刺激在全球范围内增强了Delta、theta和sigma功率，但这些振荡的交叉频率耦合的变化在空间上受到了更多的限制。重要的是，位于靶电极正后方的右侧顶区的Delta-Sigma耦合显著增加。这些发现表明，闭环式听觉刺激在目标区域局部调节Delta相和sigma功率之间的耦合，这可能被用来操纵感兴趣大脑网络中的睡眠依赖神经可塑性。
Regional changes of non-rapid eye movement (NREM) sleep delta and sigma activity, and their temporal coupling have been related to experience-dependent plastic changes during previous wakefulness. These sleep-specific rhythms seem to be important for brain recovery and memory consolidation. Recently, it was demonstrated that by targeting slow waves in a particular region at a specific phase with closed-loop auditory stimulation, it is possible to locally manipulate slow-wave activity and interact with training-induced neuroplastic changes. In our study, we tested whether closed-loop auditory stimulation targeting the up-phase of slow waves might not only interact with the main sleep rhythms but also with their coupling within the circumscribed region. We demonstrate that while closed-loop auditory stimulation globally enhances delta, theta and sigma power, changes in cross-frequency coupling of these oscillations were more spatially restricted. Importantly, a significant increase in delta-sigma coupling was observed over the right parietal area, located directly posterior to the target electrode. These findings suggest that closed-loop auditory stimulation locally modulates coupling between delta phase and sigma power in a targeted region, which could be used to manipulate sleep-dependent neuroplasticity within the brain network of interest.