Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus
Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus
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DOI：
10.1152/ajpregu.00386.2006
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发表时间：
2007-01-01
影响因子：
2.8
通讯作者：
Nelson, Randy J.
中科院分区：
文献类型：
--
作者：
Martin, Lynn B., II;Navara, Kristen J.;Nelson, Randy J.
免疫系统保护生物体免受感染，但这种保护可能是有代价的。在这里，我们询问食物限制是否会损害生物体在再次暴露于抗原时产生免疫应答的能力，这将代表免疫记忆的功能成本。当B和T淋巴细胞对病原体的成分敏感时（即，抗原）在暴露后增殖并持续存在于循环中以阻止再感染。为了测试B细胞记忆（负责抗体产生的免疫系统组分）维持起来昂贵的可能性，在食物限制和随意喂养的雄性鹿小鼠（Peromyscus maniculatus）中比较了针对新型蛋白质[匙孔血蓝蛋白（KLH）]的二次抗体产生。为了确定受损的二抗产生是否仅仅是由于皮质酮升高而与资源可用性无关，对一些食物限制和随意喂养的小鼠进行不可预测的慢性（2小时/天）限制。第一次抗原激发后2周，小鼠喂食70%的自由采食饲料，第二次抗原激发后，产生的抗KLH IgG比自由采食的小鼠少95%，即使所有小鼠在二次抗体应答期间都是自由采食的。限制没有影响二次IgG生产响应KLH，和皮质酮浓度限食后1天之间的食物限制和随意喂养的小鼠没有差异。总之，这些数据意味着二次抗体反应和免疫记忆的好处在这个物种中是非常昂贵的。
The immune system protects organisms against infection, but this protection presumably comes at a cost. Here, we asked whether food restriction would compromise the ability of an organism to generate an immune response on reexposure to an antigen, which would represent a functional cost of immunological memory. Immunological memory is generated when B and T lymphocytes sensitive to components of pathogens (i.e., antigens) proliferate after exposure and persist in circulation to hinder reinfection. To test the possibility that B cell memory, the component of the immune system responsible for antibody production, is expensive to maintain, secondary antibody production against a novel protein [keyhole limpet hemocyanin (KLH)] was compared in food-restricted and ad libitum-fed male deer mice (Peromyscus maniculatus). To determine whether compromised secondary antibody production was solely due to elevated corticosterone independent of resource availability, some food-restricted and ad libitum-fed mice were subjected to unpredictable, chronic (2 h/day) restraint. Mice fed 70% of their ad libitum diet 2 wk after primary antigen challenge produced similar to 95% less IgG against KLH after a second antigen challenge than mice fed ad libitum, even though all mice were fed ad libitum during the secondary antibody response period. Restraint had no effect on secondary IgG production in response to KLH, and corticosterone concentrations 1 day after food restriction did not differ between food-restricted and ad libitum-fed mice. Together, these data imply that secondary antibody responses and the benefits of immunological memory are energetically costly in this species.