Characteristics and pregnancy outcomes of pregnant women asymptomatic for bacterial vaginosis
Characteristics and pregnancy outcomes of pregnant women asymptomatic for bacterial vaginosis
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DOI：
10.1007/s10995-007-0239-7
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发表时间：
2008-03-01
影响因子：
2.3
通讯作者：
Friedenberg, Frank K.
中科院分区：
文献类型：
--
作者：
Nelson, Deborah B.;Bellamy, Scarlett;Friedenberg, Frank K.
研究设计确定与无症状细菌性阴道病（BV）相关的临床、行为或人口学因素，并检查有无无症状细菌性阴道病的妇女与有症状的BV阳性妇女相比，是否有更高的各种妊娠结局风险。在这项研究中，1916名怀孕12周或更短的孕妇被招募。采访者协助收集阴道拭子进行细菌性阴道炎评估，并完成基线调查问卷。革兰氏染色法鉴定BV。结果40%的孕妇BV筛查呈阳性，相当比例的BV阳性孕妇无症状（67%）。与有症状的BV阳性妇女相比，无症状的BV阳性妇女报告的压力评分较低（RR = 0.78, 95% CI: 0.67-0.89），先前的性病（RR = 1.03, 95% CI: 1.01-1.07）稍多，Mobiluncus的数量较高（RR = 1.04, 95% CI: 1.01-1.07）。我们没有发现与BV症状相关的不良妊娠结局增加。结论妊娠早期BV阳性孕妇的症状报告与应激、性传播疾病史和移植物数量有关。我们还发现，与有症状的BV阳性妇女相比，无症状的BV妇女没有增加各种不良妊娠结局的风险。
Study Design To determine the clinical, behavioral or demographic factors associated with asymptomatic bacterial vaginosis (BV) and to examine if women with asymptomatic BV had a higher risk of a variety of pregnancy outcomes compared to symptomatic BV positive women. For this study, 1916 pregnant women who were 12 weeks' gestation or less were enrolled. Interviewers facilitated vaginal swab collection for BV assessment, and completed the baseline questionnaire. BV was identified by Gram stain.Results Forty percent of pregnant women screened positive for BV and a substantial proportion of BV positive pregnant women were asymptomatic (67%). Asymptomatic BV positive women reported lower stress scores (RR = 0.78, 95% CI: 0.67-0.89), slightly more prior STD's (RR = 1.03, 95% CI: 1.01-1.07), and a higher quantity of Mobiluncus (RR = 1.04 95% CI: 1.01-1.07) compared to symptomatic BV positive women. We did not find an increase in adverse pregnancy outcomes related to BV symptomatology.Conclusion Among first trimester pregnant women, only stress, STD history, and quantity of Mobiluncus were associated with symptom reports among BV positive pregnant women. We also found that women with asymptomatic BV did not have an increased risk of a variety of adverse pregnancy outcomes compared to symptomatic BV positive women.