[Angiogenic proteins: possible markers of physiopathological processes during fetal development].
[Angiogenic proteins: possible markers of physiopathological processes during fetal development].
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[血管生成蛋白：胎儿发育过程中生理病理过程的可能标志物]。
作者：
T. Petersen;T. Larsen;H. Nielsen
怀孕涉及新血管的协调形成，这一过程被称为血管生成。一些生长因子和特异性受体，如血管内皮生长因子(VEGF)、胎盘生长因子(PlGF)和可溶性VEGF-1受体(VEGFR-1)在这一过程中起着重要作用。妊娠相关的病理条件(先兆子痫和宫内生长受限(IUGR))与这些分子的异常表达有关，这些分子的异常表达可以通过孕妇的血液成分来测量。在临床诊断明显之前使用这些标记物似乎是可行的。病理条件，如炎症和癌症，也会诱导血管生成。对其他内皮衍生分子的测量可能会增加血管生成蛋白作为标志物的特异性和敏感性。
Pregnancy involves the coordinated formation of new vessels, a process known as angiogenesis. Several growth factors and specific receptors, e.g. vascular endothelial growth factor (VEGF), PlGF (placenta growth factor) and the soluble VEGF-1 receptor (VEGFR-1) play essential roles in the process. Pregnancy-related pathological conditions (preeclampsia and intrauterine growth restriction (IUGR)) are associated with aberrant expressions of these molecules, which can be measured in blood fractions from pregnant women. Using these as markers before a clinical diagnosis is evident, seems feasible. Pathological conditions, such as inflammation and cancer, also induce angiogenesis. Measurements of other endothelium-derived molecules may add to the specificity and sensitivity of angiogenic proteins as markers.