Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.
Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.
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平衡中的痛苦：有害事件涉及相反的过程，同时调节伤害性反应。
DOI：
10.1037/0735-7044.118.6.1418
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Meagher,MaryW
中科院分区：
文献类型：
--
作者：
Crown,EricD;Grau,JamesW;Meagher,MaryW
Studies have shown that noxious cutaneous stimulation engages physiologically different antinociceptive systems to inhibit a spinal reflex, tail withdrawal from radiant heat. Two experiments are reported that examine the relationship between the inhibition of the tail-flick response and brain-mediated responses to nociception. The induction of a spinally mediated antinociception was accompanied by an increase in latency to vocalize to a noxious thermal stimulus, suggesting pain inhibition. Physiological manipulations that eliminated the inhibition of the tail-flick reflex restored vocalization to thermal stimulation and revealed a concurrent sensitization that generally heightened behavioral reactivity. The results suggest that net pain is regulated by 2 opposing processes, a selective inhibition of nociceptive signals within the spinal cord and a general sensitization that heightens stimulus processing.
