The Incidence and Prevalence of Systemic Lupus Erythematosus in San Francisco County, California: The California Lupus Surveillance Project
The Incidence and Prevalence of Systemic Lupus Erythematosus in San Francisco County, California: The California Lupus Surveillance Project
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DOI：
10.1002/art.40191
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发表时间：
2017-10-01
影响因子：
13.3
通讯作者：
Helmick, Charles G.
中科院分区：
文献类型：
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作者：
Dall'Era, Maria;Cisternas, Miriam G.;Helmick, Charles G.
客观的。对美国系统性红斑狼疮 (SLE) 发病率和患病率的估计差异很大。本研究的目的是开展加州狼疮监测项目 (CLSP)，以确定 SLE 发病率和患病率的可靠估计，特别关注西班牙裔和亚洲裔。方法。 CLSP 由疾病控制与预防中心资助，是一个以人群为基础的登记册，登记了 2007 年 1 月 1 日至 2009 年 12 月 31 日期间居住在加利福尼亚州旧金山县的 SLE 患者。数据来源包括医院、风湿病专家、肾病专家、商业实验室和州立医院出院数据库。我们提取病历来确定 SLE 病例，我们将其定义为符合美国风湿病学会 11 项 SLE 分类标准中的 4 项的患者。我们估计了粗略和年龄标准化的发病率和患病率，并按性别和种族/民族进行分层。结果。总体年龄标准化年发病率为每 10 万人年 4.6 例。年平均经期患病率为每 10 万人 84.8 次。女性和男性的年龄标准化发病率分别为每 10 万人年 8.6 例和 0.7 例。该比率在黑人女性中最高（30.5），其次是西班牙裔女性（8.9）、亚裔女性（7.2）和白人女性（5.3）。每 10 万人中女性的年龄标准化患病率在黑人中为 458.1，在西班牙裔中为 177.9，在亚洲人中为 149.7，在白人中为 109.8。捕获-再捕获模型估计了 33 个额外的事件病例和 147 个额外的流行病例。结论。包括深入病例发现在内的综合方法可以对西班牙裔和亚洲人的 SLE 进行更可靠的估计，并确认 SLE 的种族和民族差异。 SLE 的疾病负担在黑人女性中最高，其次是西班牙裔女性、亚洲女性和白人女性。
Objective. Estimates of the incidence and prevalence of systemic lupus erythematosus (SLE) in the US have varied widely. The purpose of this study was to conduct the California Lupus Surveillance Project (CLSP) to determine credible estimates of SLE incidence and prevalence, with a special focus on Hispanics and Asians.Methods. The CLSP, which is funded by the Centers for Disease Control and Prevention, is a population-based registry of individuals with SLE residing in San Francisco County, CA, from January 1, 2007 through December 31, 2009. Data sources included hospitals, rheumatologists, nephrologists, commercial laboratories, and a state hospital discharge database. We abstracted medical records to ascertain SLE cases, which we defined as patients who met 4 of the 11 American College of Rheumatology classification criteria for SLE. We estimated crude and age-standardized incidence and prevalence, which were stratified by sex and race/ethnicity.Results. The overall age-standardized annual incidence rate was 4.6 per 100,000 person-years. The average annual period prevalence was 84.8 per 100,000 persons. The age-standardized incidence rate in women and men was 8.6 and 0.7 per 100,000 person-years, respectively. This rate was highest among black women (30.5), followed by Hispanic women (8.9), Asian women (7.2), and white women (5.3). The age-standardized prevalence in women per 100,000 persons was 458.1 in blacks, 177.9 in Hispanics, 149.7 in Asians, and 109.8 in whites. Capture-recapture modeling estimated 33 additional incident cases and 147 additional prevalent cases.Conclusion. Comprehensive methods that include intensive case-finding provide more credible estimates of SLE in Hispanics and Asians, and confirm racial and ethnic disparities in SLE. The disease burden of SLE is highest in black women, followed by Hispanic women, Asian women, and white women.