Ossifying fibromyxoid tumor: Invariable ultrastructural features and diverse immunophenotypic expression
Ossifying fibromyxoid tumor: Invariable ultrastructural features and diverse immunophenotypic expression
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DOI：
10.1080/01913120701351157
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发表时间：
2007-01-01
影响因子：
1
通讯作者：
Hasegawa, Tadashi
中科院分区：
文献类型：
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作者：
Hirose, Takanori;Shimada, Shio;Hasegawa, Tadashi
骨化性纤维粘液样肿瘤(OFMT)是一种少见的神秘软组织肿瘤，其起源尚不清楚。作者报告3例发生在成人躯干和头颈部的OFMT。2例复发，1例怀疑有转移，所有肿瘤均由多个结节组成，瘤细胞呈片状或多角形排列在纤维粘液样背景内。所有肿瘤均可见特征性的壳状骨组织。根据Folpe等人提出的分级系统，2例为恶性OFMT，1例为典型。除S-100蛋白外，1例和2例肿瘤中分别检测到细胞角蛋白和神经元标志物(神经丝、CD56或CD57)。突出和不变的超微结构特征包括重复的基底板，这似乎是诊断的关键。
Ossifying fibromyxoid tumor (OFMT) is a rare enigmatic soft tissue tumor, the origin of which is still uncertain. The authors report on 3 cases of OFMT arising in the trunk and head and neck regions of adults. Two recurred and one was suspected to have metastasis, All tumors consisted of multiple nodules, in which round or polygonal tumor cells were arranged in sheets or cords within a fibromyxoid background. Characteristic shell-like bone tissues were recognized in all tumors. Based on the grading system proposed by Folpe et al., 2 cases were designated as malignant OFMT and 1 as typical. In addition to S-100 protein, cytokeratin and neuronal markers (neurofilament, CD56 or CD57) were detected in 1 and 2 tumors, respectively. The salient and invariable ultrastructural features included reduplicated basal laminas, which seem to be crucial for the diagnosis.