High-throughput approach for the in situ generation of magnetic ionic liquids in parallel-dispersive droplet extraction of organic micropollutants in aqueous environmental samples
High-throughput approach for the in situ generation of magnetic ionic liquids in parallel-dispersive droplet extraction of organic micropollutants in aqueous environmental samples
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在水环境样品中有机微污染物的平行分散液滴萃取中原位生成磁性离子液体的高通量方法
DOI：
10.1016/j.talanta.2020.121759
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发表时间：
2021
期刊：
影响因子：
6.1
通讯作者：
Carasek, Eduardo
中科院分区：
文献类型：
--
作者：
Will, Camila;Huelsmann, Ricardo Dagnoni;Mafra, Gabriela;Merib, Josias;Anderson, Jared L.;Carasek, Eduardo
在这项工作中，首次展示了一种基于疏水性 MIL（[Co(C4IM)4+2]2[NTf2-]、[Ni(C4IM)4+2]2[NTf2-] 和 [Ni(BeIM)4+2]2[NTf2-]）原位形成的新型高通量平行分散液滴萃取 (Pa-DDE)，用于测定二苯甲酮、异丙甲草胺、水性环境样品中的三氯卡班、二甲戊灵、4-甲基亚苄基樟脑和 4-甲氧基肉桂酸 2-乙基己酯。该实验装置由包含一组磁针的 96 孔板系统组成，这些磁针用于在原位形成后收集 MIL 液滴。这一综合系统可一步同时提取多达 96 个样品并进行 MIL 生产。使用该设备，每个样品的样品制备时间为 0.78 分钟。使用单变量和多变量方法仔细优化实验条件。最佳条件包括用于原位形成的样品体积为 1.25 mL、4 mg [Co(C4IM)4+2]2[Cl−] 和 40 μL LiNTf2，并稀释在 20 μL 乙腈中。成功确定了分析质量参数，LOD 范围为 7.5 至 25 µg L−1，测定系数高于 0.989。日内和日间精密度范围分别为 6.4 至 20.6% (n = 3) 和 11.6–22.9% (n = 9)，分析物相对回收率范围为 53.9 至 129.1%。
In this work, a novel and high-throughput parallel-dispersive droplet extraction (Pa-DDE) based onin situformation of the hydrophobic MILs ([Co(C4IM)4+2]2[NTf2-], [Ni(C4IM)4+2]2[NTf2-] and [Ni(BeIM)4+2]2[NTf2-]) is demonstrated, for the first time, for the determination of benzophenone, metolachlor, triclocarban, pendimethalin, 4-methylbenzylidene camphor, and 2-ethylhexyl-4-methoxycinnamate from aqueous environmental samples. This experimental setup is comprised of a 96-well plate system containing a set of magnetic pins which were used to collect the MIL droplet afterin situformation. This consolidated system enabled simultaneous extraction of up to 96 samples and MIL production in one step. Using this apparatus, sample preparation times of 0.78 min per sample was achieved. The experimental conditions were carefully optimized using uni and multivariate approaches. The optimal conditions were comprised of sample volume of 1.25 mL, 4 mg of [Co(C4IM)4+2]2[Cl−] and 40 μL of LiNTf2for thein situformation, and dilution in 20 μL of acetonitrile. The analytical parameters of merit were successfully determined with LODs ranging from 7.5 to 25 μg L−1and coefficients of determination higher than 0.989. Intraday and interday precision ranged from 6.4 to 20.6% (n = 3) and 11.6–22.9% (n = 9), respectively, with analyte relative recovery ranging between 53.9 and 129.1%.