The Oral Microbial Consortium's Interaction with the Periodontal Innate Defense System
The Oral Microbial Consortium's Interaction with the Periodontal Innate Defense System
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DOI：
10.1089/dna.2009.0864
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发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
Darveau, Richard P.
中科院分区：
文献类型：
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作者：
Darveau, Richard P.
口腔微生物群落是与人类宿主相关的特征最为明确的多微生物群落。对微生物和组织样本的大量采样表明，在牙龈沟中发现的微生物群落类型与先天宿主介质表达状况之间存在密切关联。在临床健康和患病组织中，微生物群落与先天宿主反应之间的紧密临床关联表明，口腔群落对先天防御介质的牙周组织表达有直接影响。在无菌小鼠中进行的一项初步研究表明，口腔共生群落对白细胞介素 - 1β的表达有直接影响，这表明该微生物群落可能有助于健康牙龈组织的强大保护状态。同样，牙龈卟啉单胞菌（一种与牙周炎密切相关的口腔细菌）的脂多糖成分和侵袭特性表明，它可能是口腔微生物群落的关键成员，并促使保护性牙龈先天宿主状态发生破坏性变化。
The oral microbial consortium is the most characterized polymicrobial microbial community associated with the human host. Extensive sampling of both microbial and tissue samples has demonstrated that there is a strong association between the type of microbial community found in the gingival crevice and the status of innate host mediator expression. The strong clinical association between the microbial community and the innate host response in both clinically healthy and diseased tissue suggests that the oral consortium has a direct effect on periodontal tissue expression of innate defense mediators. A preliminary study in germ-free mice has demonstrated that the oral commensal consortium has direct effect on IL-1 beta expression, indicating that this microbial community may contribute to the strong protective status of healthy gingival tissue. Likewise, the lipopolysaccharide composition and invasion characteristics of Porphyromonas gingivalis, an oral bacterium strongly associated with periodontitis, suggest that it may be a keystone member of the oral microbial community and facilitate a destructive change in the protective gingival innate host status.