The effect of copper supplementation on the concentration of copper in the brain of the brindled mouse.
The effect of copper supplementation on the concentration of copper in the brain of the brindled mouse.
复制标题
补充铜对斑纹小鼠大脑中铜浓度的影响。
DOI：
10.1042/bj2050485
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Suzuki,K
中科院分区：
文献类型：
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作者：
Wenk,G;Suzuki,K
斑纹突变小鼠是研究门克斯卷发综合症的有用模型。人类和啮齿动物的代谢功能障碍与生物可利用铜水平不足有关。最近，铜补充疗法既能够预防各种神经病理变化的出现，又能延长这些突变小鼠的寿命。最佳补充条件是在出生后第 7 天和第 10 天进行两次腹腔注射。本研究报告了腹腔铜治疗之前、期间和之后的脑铜浓度。结果表明，出生后第 7 天和第 10 天对应于铜稳态的两个重要时期。补充疗法似乎提供了足够的生物可利用铜来满足动物在这些关键时间点的需求。讨论了这些结果对人类铜紊乱的重要性。
The brindled mutant mouse is a useful model to study Menkes kinky-hair syndrome. The metabolic dysfunctions in both human and rodent are related to insufficient levels of bioavailable copper. Recently, copper supplementation therapy has been able both to prevent the appearance of various neuropathological changes and to prolong the life of these mutant mice. The optimum conditions for supplementation have been shown to be two intraperitoneal injections on postnatal days 7 and 10. The present study reports on the brain copper concentrations before, during and after the intraperitoneal copper therapy. The results demonstrate that postnatal days 7 and 10 correspond to two important epochs in copper homoeostasis. The supplementation therapy seems to provide sufficient bioavailable copper to respond to the needs of the animal at these crucial time points. The results are discussed in terms of their importance to the human copper disorder.