1 ALPHA-HYDROXY DERIVATIVE OF VITAMIN-D3 - HIGHLY POTENT ANALOG OF 1 ALPHA, 25-DIHYDROXYVITAMIN-D3
1 ALPHA-HYDROXY DERIVATIVE OF VITAMIN-D3 - HIGHLY POTENT ANALOG OF 1 ALPHA, 25-DIHYDROXYVITAMIN-D3
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DOI：
10.1126/science.180.4082.190
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发表时间：
1973-01-01
期刊：
影响因子：
56.9
通讯作者：
DELUCA, HF
中科院分区：
文献类型：
--
作者：
HOLICK, MF;SEMMLER, EJ;DELUCA, HF
用化学方法合成了维生素D3的1α-羟基衍生物，并对其生物活性进行了测定。该类似物在刺激正常和无肾大鼠的肠道钙转运和骨钙动员方面具有与1，25-二羟基维生素D3相当的生物活性。由于1α-羟基衍生物是由胆固醇合成的，其制备比1α，25-二羟基衍生物更容易、更便宜，是治疗肾性骨营养不良和甲状旁腺功能减退症的理想药物。
The 1α-hydroxy derivative of vitamin D3has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D3in the stimulation of intestinal calcium transport and bone calcium mobilization in normal and anephric rats. Because the 1α-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1α,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypoparathyroidism.