MULTIPLE CLASSES OF DOPAMINE RECEPTORS IN MAMMALIAN CENTRAL NERVOUS-SYSTEM - INVOLVEMENT OF DOPAMINE-SENSITIVE ADENYLYL CYCLASE
MULTIPLE CLASSES OF DOPAMINE RECEPTORS IN MAMMALIAN CENTRAL NERVOUS-SYSTEM - INVOLVEMENT OF DOPAMINE-SENSITIVE ADENYLYL CYCLASE
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DOI：
10.1016/0024-3205(78)90157-1
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发表时间：
1978-01-01
期刊：
影响因子：
6.1
通讯作者：
KEBABIAN, JW
中科院分区：
文献类型：
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作者：
KEBABIAN, JW
两类多巴胺受体机制是根据它们与多巴胺敏感的腺酰环化酶的联系或独立来定义的。与腺酰环化酶无关的多巴胺受体被指定为阿尔法型。与腺酰环化酶相连的多巴胺受体被指定为Beta型。药物区分这两种受体机制。多巴胺能麦角体(利尿胺、乐格曲利和CB-154)及其拮抗剂(如甲氧氯普胺)对垂体前叶的α-多巴胺受体具有相对专一性。其他激动剂(如阿朴吗啡和多巴胺)和拮抗剂(如抗精神病药物吩噻嗪和丁苯酮)影响这两类受体。
Two classes of dopamine receptor mechanism are defined according to their association with, or independence from, a dopamine-sensitive adenylyl cyclase. Dopamine receptors unrelated to adenylyl cyclase are designated type alpha. Dopamine receptors linked to adenylyl cyclase are designated type beta. Drugs discriminate between the two receptor mechanisms. The dopaminergic ergots (lisuride, lergotrile and CB-154) and their antagonists (such as metoclopramide) are relatively specific for the alpha-dopaminergic receptor in the anterior pituitary. Other agonists (e.g. apomorphine and dopamine) and antagonists (e.g. antipsychotic phenothiazines and butyrophenones) affect both classes of receptor.