A Pilot Study of Continuous Limited-Channel aEEG in Term Infants with Encephalopathy
A Pilot Study of Continuous Limited-Channel aEEG in Term Infants with Encephalopathy
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DOI：
10.1016/j.jpeds.2009.01.002
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发表时间：
2009-06-01
影响因子：
5.1
通讯作者：
Inder, Terrie
中科院分区：
文献类型：
--
作者：
Lawrence, Russell;Mathur, Amit;Inder, Terrie
目的评价有限通道幅度积分脑电(AEEG)监测脑病患儿的准确性、可行性和影响。同时收集12小时的常规脑电视频(CEEG)。婴儿被随机分配到临床团队盲目或可见的监测中。如果在可见组中发生癫痫检测事件，临床研究小组基于对有限通道AEEG的审查，解释该事件是否伴有癫痫发作。结果在有限通道AEEG监测中，每个婴儿在超过68小时的时间内发生1116次癫痫发作(90%临床无声)，其中615次发作事件检测器检测到615次发作(55%)。随着癫痫发作持续时间的增加，检测率提高(73%>；30秒，87%>；60秒)。床边的医生能够准确地使用这个算法来区分真实的癫痫发作和假阳性。与盲组相比，可见组的癫痫负荷降低了52%(P=.114)。结论有限通道AEEG对癫痫的监测能够准确地解释癫痫发作，与cEEG相比具有更好的优势，并与癫痫负荷减轻的趋势有关。(《儿科杂志》2009；154：835-41)
Objective To evaluate the accuracy, feasibility, and impact of limited-channel amplitude integrated electroencephalogram (aEEG) monitoring in encephalopathic infants.Study design Encephalopathic infants were placed on limited-channel aEEG with a software-based seizure event detector for 72 hours. A 12-hour epoch of conventional EEG-video (cEEG) was simultaneously collected. Infants were randomly assigned to monitoring that was blinded or visible to the clinical team. If a seizure detection event occurred in the visible group, the clinical team interpreted whether the event wits a seizure, based on review of the limited-channel aEEG. EEG data were reviewed independently offline.Results in more than 68 hours per infant of limited-channel aEEG monitoring, 1116 seizures occurred (>90% clinically silent), with 615 detected by the seizure event detector (55%). Detection improved with increasing duration of seizures (73% >30 seconds, 87% >60 seconds). Bedside physicians were able to accurately use this algorithm to differentiate true seizures from false-positives. The visible group had a 52% reduction in seizure burden (P = .114) compared with the blinded group.Conclusions Monitoring for seizures with limited-channel aEEG can be accurately interpreted, compares favorably with cEEG, and is associated with a trend toward reduced seizure burden. (J Pediatr 2009;154:835-41)