Type 2 diabetic mice have increased arteriolar tone and blood pressure - Enhanced release of COX-2-derived constrictor prostaglandins
Type 2 diabetic mice have increased arteriolar tone and blood pressure - Enhanced release of COX-2-derived constrictor prostaglandins
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DOI：
10.1161/01.atv.0000172688.26838.9f
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发表时间：
2005-08-01
影响因子：
8.7
通讯作者：
Kaley, G
中科院分区：
文献类型：
--
作者：
Bagi, Z;Erdei, N;Kaley, G
客观 2 型糖尿病 (T2-DM) 经常与血管功能障碍和血压升高相关，但其潜在机制尚不完全清楚。我们假设，在 T2-DM 中，由于局部血管舒缩机制的变化，外周血管阻力的调节发生了改变。 方法和结果 - 在 T2-DM 小鼠 (C57BL/KsJ-db(-)/db(-)) 中，通过尾套法测量的收缩压和平均动脉压与对照 (db(+)/db(-)) 动物相比显着升高 (db/db, 146 +/- 5 和与对照相比，分别为 106 +/- 2 mm Hg、133 +/- 4 和 98 +/- 4 mm Hg；
Objective-Type 2 diabetes mellitus (T2-DM) is frequently associated with vascular dysfunction and elevated blood pressure, yet the underlying mechanisms are not completely understood. We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms.Methods and Results-In mice with T2-DM (C57BL/KsJ-db(-)/db(-)), systolic and mean arterial pressures measured by the tail cuff method were significantly elevated compared with those of control (db(+)/db(-)) animals (db/db, 146 +/- 5 and 106 +/- 2 mm Hg versus control, 133 +/- 4 and 98 +/- 4 mm Hg, respectively; P