Impaired spatial learning after saturation of long-term potentiation
Impaired spatial learning after saturation of long-term potentiation
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DOI：
10.1126/science.281.5385.2038
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发表时间：
1998-09-25
期刊：
影响因子：
56.9
通讯作者：
Morris, RGM
中科院分区：
文献类型：
--
作者：
Moser, EI;Krobert, KA;Morris, RGM
如果信息是以活动驱动的海马结构突触重量增加的形式存储的，那么海马长时程增强（LTP）的饱和应该会损害学习。在这里，大鼠的一个海马已被损坏，植入了多电极刺激阵列，并进入角束传入到其他海马。重复交叉束强直引起累积增强。残余突触可塑性通过在束的中心强直化幼稚测试电极来评估。在没有残留LTP的动物中，空间学习被破坏，
If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naive test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (