The relationship of local cerebral glucose utilization to optical density ratios.
The relationship of local cerebral glucose utilization to optical density ratios.
复制标题
局部脑葡萄糖利用率与光密度比的关系。
DOI：
10.1016/0006-8993(83)91204-0
复制
发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
Ryan,AF
中科院分区：
文献类型：
--
作者：
Sharp,FR;Kilduff,TS;Bzorgchami,S;Heller,HC;Ryan,AF
通过比较同一动物的局部脑葡萄糖利用率（LCGU）和光密度（OD）比率，评估[14C]2-脱氧葡萄糖神经解剖作图实验中使用的光密度比的有效性。OD比的计算方法是将每只动物不同灰质结构的光密度除以单一白质结构的光密度。在一个给定的动物体内，包括受刺激的、高度激活的区域，OD比与LCGU呈线性相关。麻醉深刻影响LCGU与OD比值的关系，但OD比值并不能提供不同生理状态下动物LCGU的准确指标。然而，麻醉对外径比只有轻微的影响，这表明外径比可能有助于评估不同生理状态下动物的结构是否被功能激活。
The validity of optical density ratios used in [14C]2-deoxyglucose neuroanatomical mapping experiments is evaluated by comparing local cerebral glucose utilization (LCGU) and optical density (OD) ratios in the same animals. OD ratios are calculated by dividing the optical density of different gray matter structures by the optical density of a single white matter structure in each animal. OD ratios are linearly related to LCGU within a given animal including stimulated, highly activated regions. Anesthesia profoundly affects the relationship between LCGU and OD ratios, however, showing that OD ratios do not provide an accurate index of LCGU between animals in different physiological states.Anesthesia had only a slight effect on OD ratios, however, indicating that OD ratios may be helpful in assessing whether structures are functionally activated between animals in different physiological states.