The role of the striatum and hippocampus in planning - A PET activation study in Parkinson's disease
The role of the striatum and hippocampus in planning - A PET activation study in Parkinson's disease
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DOI：
10.1093/brain/124.5.1020
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发表时间：
2001-05-01
期刊：
影响因子：
14.5
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
--
作者：
Dagher, A;Owen, AM;Brooks, DJ
之前的研究已经确定前额皮质（PFC）和纹状体参与运动的规划和选择。我们使用 (H2O)-O-15- PET 和伦敦塔 (TOL) 任务比较了帕金森病患者和年龄匹配的对照组在计划过程中的大脑激活模式。在这项研究中，我们的轻度帕金森病组表现与对照组相同，但表现出不同的神经元激活模式。在两组中，PFC 的重叠区域被激活，但在对照组中右侧尾状核被激活，这在帕金森病患者中并不明显。这表明，尽管基底神经节内的处理异常，帕金森病中仍可能发生正常的额叶激活。此外，对照组的右侧海马体活动受到抑制，而帕金森病患者的右侧海马体活动则增强。这可能代表帕金森病在执行 TOL 任务期间向陈述性记忆系统的转变，可能是由于额纹状体系统内工作记忆容量不足造成的。
Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in Parkinson's disease patients and age-matched controls using (H2O)-O-15- PET and the Tower of London (TOL) task. In this study, our mildly affected Parkinson's disease group performed as well as the control group but showed a different pattern of neuronal activation. In the two groups, overlapping areas of the PFC were activated but, whereas the right caudate nucleus was activated in the control group, this was not evident in the Parkinson's disease patients. This suggests that normal normal frontal lobe activation can occur in Parkinson's disease despite abnormal processing within the basal ganglia. Moreover, right hippocampus activity was suppressed in the controls and enhanced in the Parkinson's disease patients. This could represent a shift to the declarative memory system in Parkinson's disease during performance of the TOL task, possibly resulting from insufficient working memory capacity within the frontostriatal system.