Origin and Function of Epidermal Langerhans Cells
Origin and Function of Epidermal Langerhans Cells
复制标题
表皮朗格汉斯细胞的起源和功能
作者：
G. Stingl;K. Tamaki;S. Katz
1868年，医学生Paul Langerhans通过用金盐浸渍人类皮肤，在表皮的基底上区域发现了一群树突状细胞（Langerhans 1868）。这些细胞现在通常被称为朗格汉斯细胞（LC）。由于氯化金染色剂对神经组织有特殊的亲和力，朗格汉斯认为这些细胞是神经系统的一部分。这一理论一直被其他研究者坚持到20世纪60年代（Ferreira-Marques 1951，Niebauer & Sekido 1965）。在整个1950年代和1960年代，另一个假设的概念已经发展出来，它假设LC和黑素细胞之间的关系。根据该理论，LC被认为是磨损的黑素细胞（Masson 1951）、分裂的黑素细胞的子细胞（Zelickson 1966）或处于发育停滞阶段的黑素细胞（Breathnach 1963）。虽然Birbeck等人（1961）的电子显微镜研究揭示了LC含有独特的细胞质细胞器，但这些作者也支持LC来源于黑素细胞的观点。这种LC和黑素细胞之间的个体发生关系的假设以及LC是神经组织成分的建议被Breathnach等人（1968）的移植实验所推翻。这些作者将已被剥夺神经嵴成分的l（）天大的小鼠胚胎的肢芽移植到组织相容性动物的脾脏中，在那里它们继续生长和分化。LC在表皮和表皮下结缔组织中有规律地存在，
In 1868, the medical student Paul Langerhans discovered a population of dendritic cells in the suprabasal regions of the epidermis by impregnating human skin with gold salts (Langerhans 1868). These cells are now eponymously referred to as Langerhans cells (LC). Since the gold chloride stain has a particular affinity for nerve tissue, Langerhans considered these cells to be a part of the nervous system. This theory was maintained by other investigators until the 196O's {Ferreira-Marques 1951, Niebauer & Sekido 1965). Throughout the 195O's and 196O's, another hypothetical concept had evolved which postulated a relationship between LC and melanocytes. According to that theory, LC were regarded either as worn-out melanocytes (Masson 1951), as daughter cells of dividing melanocytes (Zelickson 1966), or as melanocytes in an arrested stage of development (Breathnach 1963). Although the electron microscopic studies of Birbeck et al. (1961) had revealed that LC contained unique cytoplasmic organelles, these authors also favored the view of LC being derived from melanocytes. This postulated ontogenic relationship between LC and melanocytes and the suggestion that LC were a component of nervous tissue were disproven by grafting experiments of Breathnach et al. (1968). These authors transplanted limb buds of l()-day-old mouse embryos which had been deprived of their neural crest components into the spleens of histocompatible animals where they continued to grow and to differentiate. LC were regularly found in epidermis and in subepidermal connective tissue from skin differentiated from the neural