Effects of thermal injury on skeletal metabolism in two strains of mice.
Effects of thermal injury on skeletal metabolism in two strains of mice.
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热损伤对两种品系小鼠骨骼代谢的影响。
DOI：
10.1007/s00223-001-1139-2
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Shelby,J
中科院分区：
文献类型：
--
作者：
Miller,SC;Bowman,BM;Siska,CC;Shelby,J
长期生长迟缓发生在儿童中，骨质减少发生在儿童和成年人中，他们被烧伤或遭受其他损伤，导致全身炎症反应。本研究的目的是确定一些生长，并确定松质骨和皮质骨的变化，发生在几个对比品系的小鼠热损伤。雄性C3 H/HeN和Balb/c小鼠给予约20%全身热损伤，10天后收集骨骼组织。两种品系烧伤动物的骨灰重量均低于其假手术对照组。在这两种品系中，烧伤动物的松质骨体积小于其各自的假手术组或基线对照组。骨丢失在继发性松质骨区域尤其明显，还包括骨小梁厚度和连接性降低以及骨小梁分离增加。纵向（软骨内）生长抑制烧伤动物。在烧伤的动物中，松质骨形成的指数大大减少，而皮质骨中的指数基本上不存在。烧伤后松质骨破骨细胞数量增多，皮质内侵蚀面增多。这些数据表明，在热损伤的实验模型中，骨骼的生长和代谢发生了快速而深刻的变化。一般而言，在Balb/c中观察到的相对响应大于C3 H/HeN菌株。热损伤导致骨形成和软骨内生长的快速和显着的抑制，增加松质骨和皮质骨的骨吸收。
Long-term growth retardation occurs in children and osteopenias occur among children and adults who have been burned or suffer other injuries that result in a systemic inflammatory response. The purpose of this study was to define some of the growth, and to determine cancellous and cortical bone changes that occur following thermal injury in several contrasting strains of mice. Male C3H/HeN and Balb/c mice were given about a 20% total body thermal injury and 10 days later skeletal tissues were collected. The bone ash weights of the burned animals from both strains were less than their sham controls. In both strains, cancellous bone volumes were less in the burned animals than in their respective sham or baseline control groups. The loss of bone was particularly evident in the secondary spongiosa regions and also included a decrease in trabecular thickness and connectivity and an increase in trabecular separation. Longitudinal (endochondral) growth was suppressed in the burn animals. In the burned animals, indices of cancellous bone formation were substantially reduced whereas those in cortical bone were essentially nonexistent. The numbers of osteoclasts were increased in cancellous bone, and endocortical eroded surface was increased in the burn animals. These data show that there are rapid and profound changes in skeletal growth and metabolism in an experimental model of thermal injury. In general, a greater relative response was observed in the Balb/c vs. the C3H/HeN strain. Thermal injury resulted in a rapid and dramatic suppression of bone formation and endochondral growth with increased bone resorption in both cancellous and cortical bone.
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肺同种异体移植排斥反应的诊断。
影响因子：
158.5
作者：
R. Hruban;W. Beschorner;P. Gupta;W. Baumgartner;S. Achuff;T. Traill;B. Reitz;G. Hutchins
通讯作者：
G. Hutchins
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影响因子：
39.2
作者：
L. Calabrese;M. Proffitt;B. Yen‐Lieberman;R. Hobbs;N. Ratliff
通讯作者：
N. Ratliff
有艾滋病风险的患者的免疫性血小板减少性紫癜。
影响因子：
7.4
作者：
S. Karpatkin
通讯作者：
S. Karpatkin
肿瘤坏死因子和干扰素-γ 诱导狒狒皮肤中不同的内皮激活模式和相关的白细胞积聚。
DOI：
--
发表时间：
1989
期刊：
The American journal of pathology
影响因子：
--
作者：
Munro,JM;Pober,JS;Cotran,RS
通讯作者：
Cotran,RS
肿瘤坏死因子及相关细胞因子对血管内皮细胞的影响。
DOI：
10.1002/9780470513521.ch12
发表时间：
1987
期刊：
Ciba Foundation symposium
影响因子：
--
作者：
Pober,JS
通讯作者：
Pober,JS