Detection of breast cancer with ultrasound tomography: First results with the Computed Ultrasound Risk Evaluation (CURE) prototype
Detection of breast cancer with ultrasound tomography: First results with the Computed Ultrasound Risk Evaluation (CURE) prototype
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DOI：
10.1118/1.2432161
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发表时间：
2007-02-01
期刊：
影响因子：
3.8
通讯作者：
Glide, Carri
中科院分区：
文献类型：
--
作者：
Duric, Nebojsa;Littrup, Peter;Glide, Carri
虽然乳房X线摄影是乳房成像的金标准，但其局限性导致良性病变活检率高，致密乳房女性的假阴性率高。为了应对这一成像性能差距，我们一直在开发一种基于超声断层扫描原理的临床乳腺成像方法。计算机超声风险评估（CURE）系统的设计具有全乳房、操作员独立成像和乳腺肿块鉴别的临床目标。本文介绍了第一个临床原型，总结了我们最初的图像重建技术，并提出了幻影和初步的体内结果。在对其体内性能的初步评估中，我们使用CURE原型检查了50名女性，并获得了以下结果。(1)乳腺结构的断层成像在反射和透射成像的CURE模式中得到证实。(2)在反射和4毫米的透射面内空间分辨率达到0.5毫米。(3)常规检测大小> 15 mm的肿块。(4)反射，声速和衰减成像的乳房肿块证明。这些初步结果表明，独立于操作员的全乳房成像和乳腺肿块的检测是可行的。未来的研究将集中在改进肿块的检测和鉴别上，以支持我们提高乳腺检查特异性的长期目标，从而减少良性肿块的活检数量。(c)2007年美国医学物理学家协会。
Although mammography is the gold standard for breast imaging, its limitations result in a high rate of biopsies of benign lesions and a significant false negative rate for women with dense breasts. In response to this imaging performance gap we have been developing a clinical breast imaging methodology based on the principles of ultrasound tomography. The Computed Ultrasound Risk Evaluation (CURE) system has been designed with the clinical goals of whole breast, operator-independent imaging, and differentiation of breast masses. This paper describes the first clinical prototype, summarizes our initial image reconstruction techniques, and presents phantom and preliminary in vivo results. In an initial assessment of its in vivo performance, we have examined 50 women with the CURE prototype and obtained the following results. (1) Tomographic imaging of breast architecture is demonstrated in both CURE modes of reflection and transmission imaging. (2) In-plane spatial resolution of 0.5 mm in reflection and 4 mm in transmission is achieved. (3) Masses > 15 mm in size are routinely detected. (4) Reflection, sound speed, and attenuation imaging of breast masses are demonstrated. These initial results indicate that operator-independent, whole-breast imaging and the detection of breast masses are feasible. Future studies will focus on improved detection and differentiation of masses in support of our long-term goal of increasing the specificity of breast exams, thereby reducing the number of biopsies of benign masses. (c) 2007 American Association of Physicists in Medicine.