Egr2 and Egr3 are the unique regulators for systemic autoimmunity.
Egr2 and Egr3 are the unique regulators for systemic autoimmunity.
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DOI：
10.4161/jkst.23952
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发表时间：
2013-04-01
期刊：
影响因子：
--
通讯作者：
Yamamoto K
中科院分区：
文献类型：
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作者：
Sumitomo S;Fujio K;Okamura T;Yamamoto K
全身性自身免疫的特点是广泛的炎症、自身抗体的产生和免疫复合物的沉积。系统性自身免疫的调控机制尚不完全清楚。Li等人的论文揭示了t细胞能量所需的转录因子Egr2和Egr3是全身性自身免疫性疾病的调节因子。他们发现了Egr2和Egr3通过SOCS和Batf调控细胞因子产生和细胞增殖的证据。
Systemic autoimmunity is characterized by widespread inflammation, autoantibody production and immune complex deposition. The regulatory mechanisms for the systemic autoimmunity are not fully understood. A paper by Li et al. revealed that Egr2 and Egr3, transcription factors required for T-cell anergy, are the regulators for systemic autoimmune disease. They showed evidence that Egr2 and Egr3 control cytokine productions and cell proliferation via SOCS and Batf regulation.