INCREASED PLATELET AND RED-CELL COUNTS, BLOOD-VISCOSITY, AND PLASMA-CHOLESTEROL LEVELS DURING HEAT-STRESS, AND MORTALITY FROM CORONARY AND CEREBRAL THROMBOSIS
INCREASED PLATELET AND RED-CELL COUNTS, BLOOD-VISCOSITY, AND PLASMA-CHOLESTEROL LEVELS DURING HEAT-STRESS, AND MORTALITY FROM CORONARY AND CEREBRAL THROMBOSIS
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DOI：
10.1016/0002-9343(86)90348-7
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发表时间：
1986-11-01
影响因子：
5.9
通讯作者：
CHELLIAH, R
中科院分区：
文献类型：
--
作者：
KEATINGE, WR;COLESHAW, SRK;CHELLIAH, R
热浪期间，冠状动脉和脑血栓形成造成的死亡人数显着增加。在英国的热浪中，由于空调，外部温度为34.6度，几乎没有或没有失真。C（最大）和20.8 ° C。C（≥ 100），随后是冠状动脉和脑血栓形成的死亡率高峰，1至2天后。志愿者在41.degree的流动空气中的实验暴露。6小时使核心温度上升0.84 ℃。C，体重下降1.83公斤，出汗，尽管可以喝水，心率每分钟增加32次，动脉压下降，特别是站立时。红细胞计数增加了9%，血液粘度增加了24%，主要是在第一个小时之后。血小板计数上升了18%，血小板体积下降，主要是在第一个小时。血浆胆固醇水平增加了14%，而脂蛋白组分之间的分布没有变化。这些变化似乎可以解释在炎热天气下动脉血栓形成的死亡率增加。
Recorded deaths from coronary and cerebral thrombosis rise markedly in heat waves. In a British heat wave with little or no distortion due to air-conditioning, outside temperatures of 34.6.degree. C (maximum) and 20.8.degree. C (minium) were followed by peak mortalities from coronary and cerebral thrombosis one to two days later. Experimental exposure of volunteers to moving air at 41.degree. C for six hours caused core temperature to rise 0.84.degree. C, weight to fall 1.83 kg with sweating despite access to water, heart rate to increase 32 beats per minute, and arterial pressure to fall, particularly on standing. The red blood cell count increased 9 percent, and blood viscosity increased 24 percent, mostly after the first hour. The platelet count rose 18 percent, and the platelet volume fell, mostly in the first hour. The plasma cholesterol level increased 14 percent without a change in distribution among lipoprotein fractions. The changes seem able to explain the increased mortality from arterial thrombosis in hot weather.