DNA repair: PARP - another guardian angel?
DNA repair: PARP - another guardian angel?
复制标题
DOI：
10.1016/s0960-9822(98)70032-6
复制
发表时间：
1998-01-15
期刊：
影响因子：
9.2
通讯作者：
Jeggo, PA
中科院分区：
文献类型：
--
作者：
Jeggo, PA
聚（ADP-核糖）聚合酶（PARP）缺陷的细胞系和小鼠具有升高的自发遗传重排和对应激的异常反应。这些结果可以解释由自由基诱导的损伤的反应改变，并建议PARP限制基因组的不稳定性，从这样的损害。
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.