Serum inflammatory proteins and cognitive decline in older persons
Serum inflammatory proteins and cognitive decline in older persons
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DOI：
10.1212/01.wnl.0000158281.08946.68
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发表时间：
2005-04-26
期刊：
影响因子：
9.9
通讯作者：
Eikelenboom, P
中科院分区：
文献类型：
--
作者：
Dik, MG;Jonker, C;Eikelenboom, P
目的：探讨血清炎性蛋白α(1)-抗糜蛋白酶(ACT)、C反应蛋白(CRP)、白细胞介素6(IL-6)和白蛋白水平与老年人认知功能减退的关系。方法：研究样本包括1,284名阿姆斯特丹纵向老龄化研究的参与者，年龄在62到85岁之间。以一般认知(简易智力状态检查[MMSE])、记忆(听觉言语学习测验)、流体智力(瑞文彩色递进矩阵)和信息处理速度(编码任务)为评估标准。结果：ACT的最高三分位数与MMSE(年龄、性别、教育调整后的优势比[OR]1.60；95%CI：1.05至2.43)的下降风险增加相关，但与任何其他认知测试分数无关。在我们的研究中，在任何认知测试中，CRP、IL-6和白蛋白与认知功能减退无关。结论：这项以人群为基础的研究表明，血清炎性蛋白α(1)-抗糜蛋白酶与老年人认知功能减退有关，而C反应蛋白、白细胞介素6和白蛋白与此无关。
Objective: To assess whether serum levels of the inflammatory proteins alpha(1)-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons. Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven's Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up. Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study. Conclusions: This population-based study showed that the serum inflammatory protein alpha(1)-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.