Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease
Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease
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DOI：
10.1164/rccm.2112043
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发表时间：
2002-09-01
影响因子：
24.7
通讯作者：
Antó, JM
中科院分区：
文献类型：
--
作者：
Domingo-Salvany, A;Lamarca, R;Antó, JM
为了评估一般和特定健康相关的生活质量(HRQL)是否与慢性阻塞性肺疾病(COPD)患者的总死亡率和特定死亡率独立相关，我们跟踪调查了1993-1994年间在呼吸门诊招募的321名COPD男性患者，直到1999年。在稳定的临床条件下记录的基线特征包括强迫肺活量、动脉血气紧张、呼吸困难评分、11种并存情况、圣乔治呼吸问卷(SGRQ)和SF-36健康调查。生命状态通过复查、死亡登记表和临床记录进行评估。死亡的受试者年龄较大(69.8vs62.5岁)(p<；0.001)，体重指数(Bmi)较低(25.4vs27.1)(p<；0.001)，临床特征受损更严重(%FEV1，34.0vs51.0)(p<；0.001)，接受长期氧疗的频率更高(31%vs7%)(p<；0.001)。当报告HRQL较差时，生存期较短。在COX模型中，SGRQ总分和SF-36总分与总死亡率和呼吸系统死亡率独立相关，包括年龄、FEV1和BMI。两种HRQL指标的总死亡率标准化风险比均为1.3，而FEV1的总死亡率标准化风险比为1.6。HRQL测量提供有关男性COPD患者健康状况的独立和相关信息。应该考虑使用它们来对COPD患者进行更彻底的评估和分期。
To assess whether generic and specific health-related quality of life (HRQL) are independently associated with total and specific mortality in patients with chronic obstructive pulmonary disease (COPD), we followed until 1999 a cohort of 321 male patients with COPD, recruited in 1993-1994 at outpatient respiratory clinics. Baseline characteristics recorded under stable clinical conditions included forced spirometry, arterial blood gas tensions, dyspnea scales, 11 comorbid conditions, St. George's Respiratory Questionnaire (SGRQ), and SF-36 Health Survey. Vital status was assessed through reinterviews, the Mortality Register, and clinical records. Subjects who died (106) were older (69.8 versus 62.5 years) (p < 0.001), had lower body mass index (BMI) (25.4 versus 27.1) (p < 0.01), were more impaired in the clinical characteristics studied (%FEV1, 34.0 versus 51.0) (p < 0.001), and had long-term oxygen therapy more frequently (31% versus 7%) (p < 0.001). Survival was shorter when worse HRQL was reported. SGRQ total and SF-36 physical summary scores were independently associated with total and respiratory mortality in Cox models, including age, FEV1, and BMI. The total mortality-standardized hazard ratios for both HRQL measures were 1.3, whereas those for FEV1 were 1.6. HRQL measures provide independent and relevant information on the health status of male patients with COPD. Their use should be considered for a more thorough evaluation and staging of patients with COPD.