GLUTARIMIDE ANTIBIOTIC 9-METHYLSTREPTIMIDONE - STRUCTURE, BIOGENESIS AND BIOLOGICAL-ACTIVITY
GLUTARIMIDE ANTIBIOTIC 9-METHYLSTREPTIMIDONE - STRUCTURE, BIOGENESIS AND BIOLOGICAL-ACTIVITY
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DOI：
10.1071/ch9760673
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发表时间：
1976-01-01
影响因子：
1.1
通讯作者：
RICKARDS, RW
中科院分区：
文献类型：
--
作者：
ALLEN, MS;BECKER, AM;RICKARDS, RW
链霉菌发酵中具有高抗真菌活性的抗生素是链米酮的9-甲基衍生物(1)。(1)中的共轭二烯体系具有6E，8Z立体化学性质。本文提出了该链米酮同源物中9-甲基的生物遗传学来源的证据，并将其抗真菌活性与链米酮和其他杀菌剂进行了比较。
The antibiotic responsible for the high antifungal activity of a streptomycete fermentation is the 9-methyl derivative (1) of streptimidone. The conjugated diene system in (1) is assigned the 6E,8Z stereochemistry. Evidence is presented for the biogenetic origin of the 9-methyl group in this streptimidone homologue and its antifungal activity is compared with that of streptimidone and other fungicides.