Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16
Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16
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DOI：
10.4049/jimmunol.1900101
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发表时间：
2019-07-15
影响因子：
4.4
通讯作者：
Rosenberg, Helene F.
中科院分区：
文献类型：
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作者：
Ma, Michelle;Percopo, Caroline M.;Rosenberg, Helene F.
嗜酸性白细胞在骨髓中发育并从外周血迁移到组织，在组织中它们通过释放预先形成的免疫调节介质来维持体内平衡并促进功能障碍。在这项研究中，我们探讨了人类嗜酸性粒细胞的异质性，特别关注细胞因子含量自然发生的变化。我们发现人类嗜酸性粒细胞相关细胞因子从最小（变异系数 [CV]
Eosinophilic leukocytes develop in the bone marrow and migrate from peripheral blood to tissues, where they maintain homeostasis and promote dysfunction via release of preformed immunomodulatory mediators. In this study, we explore human eosinophil heterogeneity with a specific focus on naturally occurring variations in cytokine content. We found that human eosinophil-associated cytokines varied on a continuum from minimally (coefficient of variation [CV]